Summary
Ethylene glycol (EG) was found not to alter DNA sequences inNeurospora crassa conidia, though it is believed to be mutagenic in nature. Molecular hybridization revealed 20% increase in whole RNA transcripts in EG-treated conidia, which indicates that while untreated conidia increase RNA synthesis by 2.35 fold, treated conidia are inhibited and undergo only a 1.2fold increase. Thus there is an inhibition in potential RNA synthesis, though some RNA synthesis goes on in presence of ethylene glycol.
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Thanks are due to Bhaba Atomic Research Centre, India, for financial assistance. I also thank Prof. A. K. Sharma, head of the Department for laboratory facilities.
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Chaudhuri, R.K. Effect of ethylene glycol on transcription ofNeurospora crassa conidial genome. Experientia 34, 735–736 (1978). https://doi.org/10.1007/BF01947291
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DOI: https://doi.org/10.1007/BF01947291