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Antimitotic and antiviral activities of Kelletinin A in HTLV-1 infected MT2 cells

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Abstract

Kelletinin A [ribityl-pentakis (p-hydroxybenzoate)] (KA), a natural compound isolated from the marine gastropodBuccinulum corneum, showed antiviral activity on the human T-cell leukemia virus type-1 (HTLV-1) and antimitotic activity on HTLV-1-infected MT2 cells. KA inhibited cellular DNA and RNA synthesis, without influencing protein synthesis, and interfered with viral transcription by reducing the levels of high molecular weight transcripts. Finally, the compound inhibited HTLV-1 reverse transcriptase in vitro.

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Authors and Affiliations

  1. Dipartimento di Medicina Sperimentale e Scienze Biochimiche, II Università di Roma ‘Tor Vergata’, Rome, Italy

    I. Silvestri, L. Albonici, M. Ciotti, M. P. Lombardi, P. Sinibaldi & V. Manzari

  2. Istituto Tecnologie Biomediche C.N.R., v. di Tor Vergata 134, Rome, Italy

    L. Albonici

  3. Dipartimento di Medicina Sperimentale, Università ‘La Sapienza’, Rome, Italy

    I. Silvestri & M. P. Lombardi

  4. Istituto Biochimica delle Proteine ed Enzimologia, C.N.R., v. Toiano n 6-80072 Arco Felice, Naples, Italy

    P. Orlando & F. Carretta

  5. C.N.R., Istituto Chimica Molecole Interesse Biologico, v. Toiano n 6-80072 Arco Felice, Naples, Italy

    G. Strazzullo

  6. Istituto Biochemica Macromolecole, Fac. Medicina, II Università di Napoli, v. Costantinopoli 16, Naples, Italy

    P. Grippo

Authors
  1. I. Silvestri
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  2. L. Albonici
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  3. M. Ciotti
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  4. M. P. Lombardi
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  5. P. Sinibaldi
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  6. V. Manzari
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  7. P. Orlando
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  8. F. Carretta
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  9. G. Strazzullo
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  10. P. Grippo
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Silvestri, I., Albonici, L., Ciotti, M. et al. Antimitotic and antiviral activities of Kelletinin A in HTLV-1 infected MT2 cells. Experientia 51, 1076–1080 (1995). https://doi.org/10.1007/BF01946920

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  • DOI: https://doi.org/10.1007/BF01946920

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