Skip to main content
SpringerLink
Log in

Effects of polysorbates and Cremophor EL on vascular responses in rat aorta

  • Research Articles
  • Published:
Experientia Aims and scope Submit manuscript

Abstract

The effects of Tween 20, Tween 80, and Cremophor EL, surface active agents which are used for dispersion of water-insoluble substances, on vascular responsiveness were investigated using rat aortic rings. In high concentrations all these agents produced persistent contractions in aortic rings independent of the presence of endothelium. These contractions were not influenced by inhibitors of known endogenous contractile mediators. Incubation with these agents caused a concentration-dependent inhibition of the endothelium-dependent relaxant responses to acetylcholine in intact precontracted aortic rings. Endothelium-independent relaxations produced by sodium nitroprusside were not inhibited, but rather potentiated in the presence of Tween 80 (10−1 ml/l). On the other hand, Tween 80 inhibited the contractile effects of 5-hydroxytryptamine, phenylephrine, and bradykinin significantly. The data suggests that these substances affect both endothelial cells and vascular smooth muscle.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Reynolds, J. E. F. Martindale: The Extra Pharmacopoeia (1989) 1246.

  2. Abraham, J. S., Bentley, F. R., Gavrison, R. N., and Cryer, H. M., Transplant. Proc.23 (1991) 356.

    CAS  PubMed  Google Scholar 

  3. Moore, J., J. Am. Coll. Toxic.3 (1984) 1.

    CAS  Google Scholar 

  4. Abraham, J. S., Bentley, F. R., Gavrison, R. N., and Cryer, H. M., Transplantation52 (1991) 101.

    Article  CAS  PubMed  Google Scholar 

  5. Fogo, A., Hellings, S. E., Inagami, T., and Kon, V., Kidney Int.42 (1992) 770.

    Article  CAS  PubMed  Google Scholar 

  6. Gaudy, J. H., Sicard, J. F., Lhoste, F., and Boiter, J. F., Can. J. Anaesth.34 (1987) 122.

    Article  CAS  PubMed  Google Scholar 

  7. Hunter, S. C., and Thomson, D. S., Br. J. Anaesth.54 (1982) 231P.

    Google Scholar 

  8. Huttel, M. S., Schou-Olesen, A., and Stoffersen, E., Br. J. Anaesth.52 (1980) 77.

    Article  CAS  PubMed  Google Scholar 

  9. Mehring, N., Neumann, K. H., Rahn, K.-H., and Zidek, W., Nephron60 (1992) 474.

    Article  Google Scholar 

  10. Moneret-Vautrin D. A., Laxenaire, M. C., and Viry-Babel, F., Br. J. Anaesth.55 (1983) 469.

    Article  CAS  PubMed  Google Scholar 

  11. Thiel, G., Hermle, M., and Brunner, F. P., Clin. Nephrol.25(Suppl 1) (1986) 540.

    Google Scholar 

  12. Zhao, F. K., Chuang, L. F., Israel, M., and Chuang, R. Y., Biochem. biophys. Res. Commun.159 (1989) 1359.

    Article  CAS  PubMed  Google Scholar 

  13. Alade, S. L., Brown, R. E., and Paquet, A., Pediatrics77 (1986) 593.

    Article  CAS  PubMed  Google Scholar 

  14. Arrowsmith, J. B., Faich, G. A., Tomita, D. K., Kuritsky, J. N., and Rosa, F. W., Pediatrics83 (1989) 244.

    Article  CAS  PubMed  Google Scholar 

  15. Balistreri, W. F., Farrell, M. K., and Bove, K. E., Pediatrics78 (1986) 503.

    Article  CAS  PubMed  Google Scholar 

  16. Bove, K. E., Kosmetatos, N., Wedig, K. E., Frank, D. J., Whitletach, S., Saldivar, J., Haas, J., Bodenstein, C., and Balistreri, W. F., J. Am. med. Assoc.254 (1985) 2422.

    Article  CAS  Google Scholar 

  17. Gough, W. B., Zeiler, R. H., Barreca, P., and El Sherif, N. J., Cardiovasc. Pharmac.4 (1982) 375.

    Article  CAS  Google Scholar 

  18. Martone, W. J., Williams, W. W., Mortensen, M. L., Gaynes, R. P., White, J. W., Lorch, V., Murphy, D., Sinha, S. N., Frank, D. J., Kosmetatos, N., Bodenstein, C. J., and Roberts R. J., Pediatrics78 (1986) 591.

    CAS  PubMed  Google Scholar 

  19. Masini, E., Planchenault, J., Pezziardi, F., Gautier, P., and Gagnol, J. P., Agents Actions16 (1985) 470.

    Article  CAS  PubMed  Google Scholar 

  20. Munoz, A., Karila, P., Gallay, P., Zettelmeier, F., Messner, P., Mery, M., and Grolleau, R., Eur. Heart J.9 (1988) 142.

    Article  CAS  PubMed  Google Scholar 

  21. Peeters, B. W., Cheung, K. S., Vossen, J. M., and Coenen, A. M., Brain Res. Bull.29 (1992) 515.

    Article  CAS  PubMed  Google Scholar 

  22. Reyniers, J. P., Machado, E. A., and Farkas, W. R., Prog. clin. biol. Res.181 (1985) 91.

    CAS  PubMed  Google Scholar 

  23. Varma, R. K., Kaushal, R., Junnarkar, A. Y., Thomas, G. P., Naidu, M. U. R., Singh, P. P., and Tripathi, R. M., Arzneimittel Forsch. Drug Res.35 (1985) 804.

    CAS  Google Scholar 

  24. Yaris, E., Tuncer, M., and Ilhan, M., Clin. Sci83 (1992) 179.

    Article  CAS  Google Scholar 

  25. Lodge, N. J., J. Pharmac. expl Ther.271 (1994) 730.

    CAS  Google Scholar 

  26. Feddersen, C. O., McMurtry, I. F., Henson P., and Voelkel, N. F., Am. Rev. respir. Dis.133 (1986) 197.

    CAS  PubMed  Google Scholar 

  27. Byfield, R. A., Swane, G. T. G., and Warner, T. J., Br. J. Pharmac.88 (1986) 436P.

    Google Scholar 

  28. Cusma-Pelògia, N., Oliveira, S. F., Nigro, D., de Carvalho, M. H. C., Scivoletto, R., and Fortes, Z. B., J. pharmac. toxic. Meth.29 (1993) 157.

    Article  Google Scholar 

  29. Hiley, C. R., Phoon, C. K. L., and Thomas, G. R., Br. J. Pharmac.91 (1987) 378P.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmacology, Gazi University Medical School, Bahcelievler, P.K. 49, 06502, Ankara, Turkey

    H. Zengil, U. Hodoĝlugil & Z. Güney

Authors
  1. H. Zengil
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. U. Hodoĝlugil
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Z. Güney
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zengil, H., Hodoĝlugil, U. & Güney, Z. Effects of polysorbates and Cremophor EL on vascular responses in rat aorta. Experientia 51, 1055–1059 (1995). https://doi.org/10.1007/BF01946915

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01946915

Key words

Search

Navigation