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Regulation ofL-valine absorption by opioids interacting withμ-receptors in rabbit ileum

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Abstract

In intact tissue, [d-Ala2,MePhe4, Gly-ol5] enkephalin (10−5 M;μ-ligand), diminsihed short-circuit current (Isc) and increased water, Na+ and Cl− net fluxes in vitro under open circuit conditions; it also inhibitedL-valine absorption andL-valine-dependent variations of short-circuit current (ΔIsc, val). Naloxone (10−6 M) antagonized these effects. In the absence of the muscularis and myenteric plexus this enkephalin or morphine (μ-ligand) reduced Isc and ΔIsc, val. These enkephalin effects occurred at different times. Different concentrations of enkephalin were tested for their effects on ΔIsc, val. [d-Ala2,d-Leu5] enkephalin (mainly a σ-ligand) significantly decreased Isc but not ΔIsc, val. The reduction ofL-valine absorption does not depend on the effects on basal ion transport. Interaction of opioids withμ-receptors located in the submucosal plexus and/or in the epithelial cell accounts for this reduction. This enkephalin effect seems to be at least partially under the control of the myenteric plexus.

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References

  1. Cooke, H. J., in: Physiology of the Gastrointestinal Tract, 2nd edn, vol. 2, p. 1307. Ed. L. R. Johnson. Raven, New York 1987.

    Google Scholar 

  2. Powell, D. W., in: Physiology of the Gastrointestinal Tract, 2nd edn, vol. 2, p. 1267. Ed. L. R. Johnson. Raven, New York 1987.

    Google Scholar 

  3. Tapper, E. J., Am. J. Physiol.244 (1983) G457.

    CAS  PubMed  Google Scholar 

  4. Hughes, J., Trends pharmac. Sci.2 (1981) 21.

    Article  CAS  Google Scholar 

  5. Fondacaro, J. D., Am. J. Physiol.250 (1986) G1.

    Article  CAS  PubMed  Google Scholar 

  6. Jaffe, J. H., and Martin, W. R., in: The Pharmacological Basis of Therapeutics, 8th edn, p. 485. Eds A. Goodman Gilman, W. T. Rall, A. S. Nies and P. Taylor. Pergamon, New York 1990.

    Google Scholar 

  7. Atkinson, R. L., Fedn Proc.46 (1987) 178.

    CAS  Google Scholar 

  8. Dockray, G. J., in: Physiology of the Gastrointestinal Tract, 2nd edn, vol. 1, p. 41. Ed. L. R. Johnson. Raven, New York 1987.

    Google Scholar 

  9. Brantl, V., Teschemacher, H., Henschen, A., and Lottspeich, F., Hoppe-Seyler's Z. physiol. Chem.360 (1979) 1211.

    Article  CAS  Google Scholar 

  10. Hautfeuille, M., Brandtl, V., Dumontier, A. M., and Desjeux, J. F., Am. J. Physiol.250 (1986) G92.

    Google Scholar 

  11. Tome, D., Dumontier, A. M., Hautefeuille, M., and Desjeux, J. F., Am. J. Physiol.253 (1987) G737.

    CAS  PubMed  Google Scholar 

  12. Zioudrou, C., Streaty, R. A., and Klee, W. A., J. biol. Chem.254 (1979) 2446.

    Article  CAS  PubMed  Google Scholar 

  13. Nishimura, E., Buchan, A. M. J., and McIntosh, C. H. S., Gastroenterology91 (1986) 1084.

    Article  CAS  PubMed  Google Scholar 

  14. Dashwood, M. R., Debnam, E. S., Bagnall, J., and Thompson, C. S., Eur. J. Pharmac.107 (1985) 267.

    Article  CAS  Google Scholar 

  15. Allescher, H. D., Ahmad, S., Kostka, P., Kwan, C. Y., and Daniel, E. E., Am. J. Physiol.256 (1989) G966.

    CAS  PubMed  Google Scholar 

  16. Gaginella, T. S., Rimele, T. J., and Wietecha, M., J. Physiol. Lond.335 (1983) 101.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Lopez-Ruiz, M. P., Arilla, E., Gomez-Pan, A., and Prieto, J. C., Biochem. biophys. Res. Commun.126 (1985) 404.

    Article  CAS  PubMed  Google Scholar 

  18. Binder, H. J., Laurenson, J. P., and Dobbins, J. W., Am. J. Physiol.247 (1984) G432.

    CAS  PubMed  Google Scholar 

  19. Kromer, W., Life Sci.44 (1989) 579.

    Article  CAS  PubMed  Google Scholar 

  20. Kachur, J. F., Miller, R. J., and Field, M., Proc. natl Acad. Sci. USA77 (1980) 2753.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Coupar, I. M., Life Sci.41 (1987) 917.

    Article  CAS  PubMed  Google Scholar 

  22. McKay, J. S., Linaker, B. D., and Turnberg, L. A., Gastroenterology80, (1981) 279.

    Article  CAS  PubMed  Google Scholar 

  23. Fogel, R., and Kaplan, R. B., Am. J. Physiol.246 (1984) G386.

    CAS  PubMed  Google Scholar 

  24. Ermisch, A., Brust, P., and Brandsch, M., Biochim. biophys. Acta982 (1989) 79.

    Article  CAS  PubMed  Google Scholar 

  25. Meyer, G., Bottà, G., Rossetti, C., and Cremaschi, D., Archs int. Physiol. Biochim.97 (1989) 65.

    CAS  Google Scholar 

  26. Meyer, G., Bottà, G., Tavani, A., Algeri, S., and Cremaschi, D., J. Pharm. Pharmac.41 (1989) 494.

    Article  CAS  Google Scholar 

  27. Kosterlitz, H. W., and Paterson, S. J., Br. J. Pharmac.73 (1981) 299P.

    Article  Google Scholar 

  28. Gillan, M. G. C., and Kosterlitz, H. W., Br. J. Pharmac.77 (1982) 461.

    Article  CAS  Google Scholar 

  29. Dobbins, J., Racusen, L., and Binder, H. J., J. clin. Invest.66 (1980) 19.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Faelli, A., Esposito, G., and Capraro, V., Biochim. biophys. Acta.455 (1976) 759.

    Article  CAS  PubMed  Google Scholar 

  31. Field, M., Fromm, D., and McColl, I., Am. J. Physiol.220 (1971) 1388.

    Article  CAS  PubMed  Google Scholar 

  32. Kachur, J. F., Miller, R. J. Eur. J. Pharmac.81 (1982) 177.

    Article  CAS  Google Scholar 

  33. Tosco, M., Orsenigo, M. N., Esposito, G., and Faelli, A., Proc. Soc. expl Biol. Med.188 (1988) 122.

    Article  CAS  Google Scholar 

  34. Levina, N. V., and Nazimov, I. V., J. Chromat.286 (1984) 207.

    Article  CAS  Google Scholar 

  35. Holm, S., Scand. J. Statist.6 (1979) 65.

    Google Scholar 

  36. Powell, D. W., in: Physiology of Membrane Disorders, 2nd edn, p. 559. Eds. T. E. Andreoli, J. F. Hoffman, D. D. Fanestil and S. G. Schultz. Plenum, New York 1986.

    Chapter  Google Scholar 

  37. Rhoads, D. E., Peterson, N. A., and Raghupathy, E., J. biol. Chem.258 (1983) 12233.

    Article  CAS  PubMed  Google Scholar 

  38. Rhoads, D. E., Peterson, N. A., and Raghupathy, E., Biochemistry23 (1984) 117.

    Article  CAS  PubMed  Google Scholar 

  39. Hughes, J., Kosterlitz, K. W., and Smith, T. W., Br. J. Pharmac.61 (1977) 639.

    Article  CAS  Google Scholar 

  40. Kosterlitz, H. W., Proc. R. Soc. Lond.B225 (1985) 27.

    Article  CAS  PubMed  Google Scholar 

  41. Lemaire, S., and Turcotte, A., Can. J. Physiol.64 (1986) 673.

    Article  CAS  Google Scholar 

  42. McKnight, A. T., Corbett, A. D., Marcoli, M., and Kosterlitz, H. W., Neuropharmacol.24 (1985) 1011.

    Article  CAS  Google Scholar 

  43. Dockray, G. J., in: Physiology of the Gastrointestinal Tract, 2nd edn, vol. 1, p. 41. Raven, New York 1987.

    Google Scholar 

  44. Madara, J. L., and Pappenheimer, J. R., J. Membr. Biol.100 (1987) 149.

    Article  CAS  PubMed  Google Scholar 

  45. Berschneider, H. M., Martens, H., and Powell, D. W., Gastroenterology94 (1988) 127.

    Article  CAS  PubMed  Google Scholar 

  46. Pasternak, G. W., and Wood, P. J., Life Sci.38 (1986) 1889.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Dipartimento di Fisiologia e Biochimica Generali, Università degli Studi di Milano, Via Celoria 26, I-20133, Milan

    G. Meyer, G. Bottà & D. Cremaschi

  2. Dipartimento di Farmacologia, Dompé Farmaceutici, S.p.A., Milan, Italy

    G. Fedele

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  1. G. Meyer
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  2. G. Bottà
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  3. G. Fedele
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  4. D. Cremaschi
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Meyer, G., Bottà, G., Fedele, G. et al. Regulation ofL-valine absorption by opioids interacting withμ-receptors in rabbit ileum. Experientia 51, 1045–1051 (1995). https://doi.org/10.1007/BF01946913

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  • DOI: https://doi.org/10.1007/BF01946913

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