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Relationship of pharmacokinetic and metabolic parameters to the absence of physical dependence liability with thebaine-3H

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Zusammenfassung

Rasche Metabolisierung und Ausscheidung sowie Eliminierung von Thebain im Rattenhirn verursacht keine biochemische Änderung der Zellen im Zentralnervensystem, woraus die geringe physiologische Gewöhnung resultieren dürfte.

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References

  1. M. H. Seevers andL. A. Woods, Am. J. Med.14, 546 (1953).

    Article  PubMed  Google Scholar 

  2. M. H. Seevers, Fedn Proc.17, 1175 (1958).

    Google Scholar 

  3. A. L. Tatum, M. H. Seevers andK. H. Collins, J. Pharmac. exp. Ther.36, 477 (1929).

    Google Scholar 

  4. L. F. Small, N. B. Eddy, E. Mossettig andC. K. Himmelsbach, U.S. Publ. Health Rept. Suppl. (1938) p. 138.

  5. N. B. Eddy, J. Pharmac. exp. Ther.66, 182 (1939).

    Google Scholar 

  6. J. W. Sloan, J. W. Brooks, A. J. Eisenman andW. R. Martin, Psychopharmacologia3, 291 (1962).

    Article  PubMed  Google Scholar 

  7. A. Teraoka, Nippon Yakugaku Zasshi61, 396 (1965).

    Google Scholar 

  8. B. Gabor, A. K. Szabo andM. Nemeth, Acta. physiol. hung.27, 187 (1965).

    Google Scholar 

  9. R. B. Nelson andH. W. Elliott, J. Pharmac. exp. Ther.155, 516 (1967).

    Google Scholar 

  10. A. L. Misra, C. L. Mitchell andL. A. Woods, Nature232, 48 (1971).

    PubMed  Google Scholar 

  11. A. L. Misra andS. J. Mule', Nature238, 155 (1972).

    PubMed  Google Scholar 

  12. A. L. Misra andS. J. Mule', Nature241, 281 (1973).

    PubMed  Google Scholar 

  13. A. L. Misra, S. J. Mule', R. Bloch andN. L. Vadlamani, J. Pharmac. exp. Ther.185, 287 (1973).

    Google Scholar 

  14. T. Jóhannesson andL. A. Woods, Acta. pharmac. tox.21, 381 (1964).

    Google Scholar 

  15. J. W. Miller andH. W. Elliott, J. Pharmac. exp. Ther.113, 283 (1955).

    Google Scholar 

  16. H. J. Kupferberg andE. L. Way, J. Pharmac. exp. Ther.141, 105 (1963).

    Google Scholar 

  17. S. J. Mule' andL. A. Woods, J. Pharmac. exp. Ther.136, 232 (1962).

    Google Scholar 

  18. A. L. Misra,Disposition and Metabolism of Drugs of Dependence, in Chemical and Biological Aspects of Drug Dependence (Eds.S. J. Mule' andH. Brill; The Chemical Rubber Company, Cleveland, Ohio 1972), p. 219.

    Google Scholar 

  19. A. Goldstein, Pharmac. Rev.1, 102 (1949).

    Google Scholar 

  20. D. J. Blaney andL. A. Woods, J. Pharmac. exp. Ther.116, 7 (1956).

    Google Scholar 

  21. O. Borgå, D. L. Azarnoff, G. P. Forshell andF. Sjöquist, Biochem. Pharmac.18, 2135 (1969).

    Article  Google Scholar 

  22. G. Franksson andE. Änggård Acta. pharmac. tox.28, 209 (1970).

    Google Scholar 

  23. A. L. Misra, R. B. Pontani andS. J. Mule', J. Chromat.71, 554 (1972).

    Google Scholar 

  24. A. L. Misra, S. Y. Yeh andL. A. Woods, Biochem. Pharmac.19, 1536 (1970).

    Article  Google Scholar 

  25. D. H. R. Barton, Proc. chem. Soc.293 (1963).

  26. A. R. Battersby, E. Brochmann-Hanssen andJ. A. Martin, Chem. Commun.483 (1967).

  27. H. I. Parker, G. Blaschke andH. Rapoport, J. Am. chem. Soc.94, 1276 (1972).

    Article  PubMed  Google Scholar 

  28. T. Yanagita, Symposium on Drugs and Society. Fifth Int. Congress on Pharmacology, San Francisco (1972), p. 133.

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Misra, A.L., Pontani, R.B. & Mule, S.J. Relationship of pharmacokinetic and metabolic parameters to the absence of physical dependence liability with thebaine-3H. Experientia 29, 1108–1110 (1973). https://doi.org/10.1007/BF01946748

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