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Ultrastructure of renal collecting tubules following ingestion of a bipyridinium herbicide (Morfamquat)

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Zusammenfassung

Ratten, denen eine Diät mit niedrigem Gehalt von Morfamquat gefüttert wurde, zeigten nach 6–24 Wochen eine erhöhte Anzahl von Lysosomen in den Epithelzellen der Nierensammelröhren. Im Lumen waren Zelltrümmer zu sehen, die auf eine Zellnekrose im proximalen Nephron schliessen liessen. Die Mitochondrien wiesen weder quantitative noch qualitative Veränderungen auf.

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Acknowledgment. The Morfamquat and recipe of the diet have been generously provided byD. M. Ferguson, Imperial Chemical Industries Ltd., Alderley Park, Nr. Macclesfield, Cheshire, England. The technical assistance of Ms. F. Cohen is gratefully acknowledged.

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Balogh, K., Merk, F.B. Ultrastructure of renal collecting tubules following ingestion of a bipyridinium herbicide (Morfamquat). Experientia 29, 1101–1103 (1973). https://doi.org/10.1007/BF01946744

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