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Nephro- and hepatotoxicity for mice and chicks inPenicillium piceum contaminated food

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Zusammenfassung

Diäten, die mit Kulturen oder Kulturfiltraten vonPenicillium piceum kontaminiert waren, erwiesen sich an Eintagsküken als strak toxisch und verursachten bei Mäusen ausgeprägte Nieren- und Leberschädigungen. Um eventuell vorhandene Oxalsäure und Citrinin, die nephrotoxisch wirken, zu eliminieren, wurde das Kulturfiltrat mit Äther bzw. Chloroform extrahiert. Die wässrigen Lösungen des Ätherextrakts waren bei Küken stark allgemein-toxisch, während bei Mäusen nur die wässrige Lösung des Chloroformextrakts diffuse Leberzellnekrose sowie Nierenveränderungen im Sinne einer Nephritis verursachte.

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Authors and Affiliations

  1. University Biochemical Laboratories, A. C. College Campus, 600025, Madras, (India)

    V. V. Parthasarathy & E. R. B. Shanmugasundaram

Authors
  1. V. V. Parthasarathy
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  2. E. R. B. Shanmugasundaram
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Additional information

This work is sponsored and financed by the United States Department of Agriculture, under the PL. 480 Funds.

The authors wish to acknowledge Dr.K. Radha Shanmugasundaram for helpful suggestions and critical discussions. Thanks are due to Dr.Sethumadhavan and Dr.R. Parthasarathy of the Madras Veterinary College for helping in photography and reading of the slides.

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Parthasarathy, V.V., Shanmugasundaram, E.R.B. Nephro- and hepatotoxicity for mice and chicks inPenicillium piceum contaminated food. Experientia 29, 1099–1100 (1973). https://doi.org/10.1007/BF01946742

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  • DOI: https://doi.org/10.1007/BF01946742

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