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Stimulation of transcription in HEp-2 cells by UV-inactivated poliovirus type 1

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Zusammenfassung

Nach Einwirkung UV-inaktivierter Polioviren wurde eine Zunahme der Bindung von Actinomycin-D, eines unspezifischen “Modellrepressors”, durch HEp-2 Zellen um 15–21% beobachtet. Die Proteinhülle UV-inaktivierter Viren verursacht möglicherweise eine Stimulierung der Genaktivität der Wirtszellen, die normalerweise der Kontrolle des intakten Virusgenoms unterliegt.

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Authors and Affiliations

  1. Institut für Experimentelle und Klinische Virologie der DFG, Ordensmeisterstr. 48, D-1000, Berlin 42, Germany

    P. R. Lorenz

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  1. P. R. Lorenz
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Additional information

I thank MissH. Weyland, MissE. Hertl, Mrs.H. Stoye and Mrs.G. Wons for expert technical assistance. This work was supported by the Deutsche Forschungsgemeinschaft.

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Lorenz, P.R. Stimulation of transcription in HEp-2 cells by UV-inactivated poliovirus type 1. Experientia 29, 1072–1073 (1973). https://doi.org/10.1007/BF01946726

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