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Experientia

, Volume 42, Issue 5, pp 568–570 | Cite as

The effect of the phytoalexins, lubimin, (−)-maackiain, pinosylvin, and the related compounds dehydroloroglossol and hordatine M on human lymphoblastoid cell lines

  • L. Skinnider
  • A. Stoessl
Short Communications

Summary

We have tested the effect of the phytoalexins lubimin, (−)-maackiain and pinosylvin and the related compounds dehydroloroglossol and hordatine M on the growth of the human lymphoblastoid cell lines Molt and Raji. (−)-maackiain, pinosylvin and dehydroloroglossol showed significant growth inhibitory action on the cells. Suppression of [3H] thymidine and [3H] leucine uptake was tested and noted in pinosylvin and dehydroloroglossol. The phytoalexins and related compounds are widespread in plants and provide a potential source of antineoplastic substances.

Key words

Phytoalexins growth inhibitory transformed cells 

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Copyright information

© Birkhäuser Verlag 1986

Authors and Affiliations

  • L. Skinnider
    • 1
    • 2
  • A. Stoessl
    • 1
    • 2
  1. 1.Department of PathologyUniversity of SaskatchewanSaskatoonCanada
  2. 2.Research CentreAgriculture CanadaLondonCanada

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