Summary
Several tetracyclines (minocycline, doxycycline, tetracycline), in levels approximating physiologic concentrations, were found to inhibit parathyroid hormone-induced bone resorption in organ culture; the specificity of this effect was demonstrated by comparison with other (non-tetracycline) types of antibiotics. The ability of tetracyclines to inhibit bone resorption is consistent with the recent proposal by Golub et al2. that these antibiotics can inhibit mammalian collagenolytic enzymes by a mechanism unrelated to the drug's antibacterial efficacy, a property which could be therapeutically useful in diseases characterized by excessive collagen breakdown.
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Gomes, B.C., Golub, L.M. & Ramamurthy, N.S. Tetracyclines inhibit parathyroid hormone-induced bone resorption in organ culture. Experientia 40, 1273–1275 (1984). https://doi.org/10.1007/BF01946671
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DOI: https://doi.org/10.1007/BF01946671