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GABA in the caudate nucleus: A possible synaptic transmitter of interneurons

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Summary

Microiontophoretic application of GABA and its antagonist, picrotoxin, altered focal potentials evoked in the caudate nucleus by stimulation near the recording site to a much greater extent than potentials elicited by stimulation of afferent pathways, suggesting that GABA is a transmitter of interneurons in this nucleus.

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References

  1. Y. Okada, C. Nitsch-Hassler, J. S. Kim, I. J. Bak and R. Hassler, Expl. Brain Res.13, 514 (1971).

    Google Scholar 

  2. S. Fahn and L. J. Côté, J. Neurochem.15, 209 (1968).

    Google Scholar 

  3. A. Chalmers, E. G. Mc Geer, V. Wickson and P. L. Mc Geer, Comp. Gen. Pharmac.1, 385 (1970).

    Google Scholar 

  4. W. Stahl and P. D. Swanson, Neurology24, 813 (1974).

    Google Scholar 

  5. H. Urquhart, T. L. Perry, S. Hansen and J. Kennedy, J. Neurochem.24, 1071 (1975).

    Google Scholar 

  6. U. K. Rinne, H. Laaksonen, P. Riekkinen and V. Sonninen, Eur. Neurol.12, 13 (1974).

    Google Scholar 

  7. K. G. Lloyd and O. Hornykiewicz, Nature243, 521 (1973).

    Google Scholar 

  8. A. Herz and W. Zieglgänsberger, Int. J. Neuropharmac.7, 221 (1968).

    Google Scholar 

  9. F. E. Bloom, E. Costa and G. C. Salmoiraghi, J. Pharm. exp. Ther.150, 244 (1965).

    Google Scholar 

  10. G. Bernardi, M. G. Marciani, C. Morocutti and P. Giacomini, Brain Res.92, 511 (1975).

    Google Scholar 

  11. M. Yoshida and W. Precht, Brain Res.32, 225 (1971).

    Google Scholar 

  12. W. Precht and M. Yoshida, Brain Res.32, 229 (1971).

    Google Scholar 

  13. J. M. Kemp and T. P. S. Powell, Phil. Trans. R. Soc. Lond.262, 383 (1971).

    Google Scholar 

  14. P. L. Mc Geer and E. G. Mc Geer, Brain Res.91, 331 (1975).

    Google Scholar 

  15. R. Spehlmann, Brain98, 219 (1975).

    Google Scholar 

  16. J. M. Kemp and T. P. S. Powell, Phil. Trans. R. Soc. Lond.262, 413 (1971).

    Google Scholar 

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Authors and Affiliations

  1. VA Lakeside Hospital and Departments of Neurology and Pharmacology, Northwestern University Medical School, 60611, Chicago, Illinois, USA

    R. Spehlmann, K. Norcross & E. J. Grimmer

Authors
  1. R. Spehlmann
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  2. K. Norcross
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  3. E. J. Grimmer
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Additional information

This study was supported by funds from the Veterans Administration and by NIH research grant No. 06820.

We thank Kathleen Downes and Clifford Smathers for their assistance.

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Spehlmann, R., Norcross, K. & Grimmer, E.J. GABA in the caudate nucleus: A possible synaptic transmitter of interneurons. Experientia 33, 623–625 (1977). https://doi.org/10.1007/BF01946537

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  • DOI: https://doi.org/10.1007/BF01946537

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