Phalloidin poisoning of isolated hepatocytes: Inhibition of protein synthesis
Specialia
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Summary
Phalloidin added to isolated hepatocytes inhibits amino acid incorporation into protein. Inhibition is very strong with 20 μg/ml phalloidin and occurs after a lag period of about 30 min. After this period, poisoned hepatocytes also show morphological changes in their plasma membrane.
Keywords
Plasma Membrane Protein Synthesis Morphological Change Phalloidin Acid Incorporation
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References
- 3.F. Miller and O. Wieland, Virchows Arch. path. Anat. Physiol.343, 83 (1967).Google Scholar
- 4.Th. Wieland and O. Wieland, in: Microbial Toxins, vol. VIII, p. 249. Ed. S. Kadis, A. Ciegler and S. J. Ajl. Academic Press, New York 1972.Google Scholar
- 5.E. Gravela, M. F. Zuretti and G. Poli, Res. Commun. Chem. Path. Pharmac.12, 101 (1975).Google Scholar
- 6.M. N. Berry and D. S. Friend, J. Cell Biol.43, 506 (1969).Google Scholar
- 7.K. N. Jeejeebhoy, J. Ho, G. R. Greenberg, M. J. Phillips, A. Bruce-Robertson and U. Sodtke, Biochem. J.146, 141 (1975).Google Scholar
- 8.C. Waymouth, J. nat. Cancer Inst.22, 1003 (1959).Google Scholar
- 9.E. Weiss, I. Sterz, M. Frimmer and R. Kroker, Beitr. Path.150, 345 (1973).Google Scholar
- 10.M. Frimmer, Naunyn-Schmiedebergs Arch. Pharmak.269, 152 (1971).Google Scholar
- 11.M. Frimmer, J. Gries, D. Hegher and B. Schnorr, Naunyn-Schmiedebergs Arch. Pharmak.258, 197 (1967).Google Scholar
- 12.M. Frimmer and R. Kroker, Naunyn-Schmiedebergs Arch. Pharmak.278, 285 (1973).Google Scholar
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© Birkhäuser-Verlag 1977