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Immunogenicity of fatty acid anilides in rabbits and the pathogenesis of the Spanish toxic oil syndrome

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Summary

Fatty acid anilides, the major xenobiotic found in the cooking oils responsible for the Spanish toxic oil syndrome, are immunogenic for rabbits as ascertained by a skin test reaction, the characterization of specific antibodies against anilides and the immunofluorescent detection of ‘anilide dependent antigens’ in tissue slices from treated animals.

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Author notes

  1. J. L. Diez

    Present address: Instituto de Biología Celular, Centro de Investigaciones Biológicas, C.S.I.C., Arzobispo Morcillo, 4, Madrid-34, Spain

  2. J. Rodrigo

    Present address: Instituto ‘Ramón y Cajal’, Centro de Investigaciones Biológicas, C.S. I.C., Arzobispo Morcillo, 4, Madrid-34, Spain

Authors and Affiliations

  1. Unidad de Biomembranas, Instituto de Inumunología y Biología Microbiana, Centro de Investigaciones Biológicas, C.S.I.C., Velázquez, 144, Madrid-6, (Spain)

    A. Marquet, V. Larraga, J. L. Diez, C. Amela, J. Rodrigo, E. Muñoz & A. Pestaña

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  1. A. Marquet
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  2. V. Larraga
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  3. J. L. Diez
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  4. C. Amela
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  5. J. Rodrigo
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  6. E. Muñoz
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  7. A. Pestaña
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Additional information

Acknowledgments. This work was supported by a grant from the Fondo de Investigaciones Sanitarias to the C.S.I.C. Programme on Toxic Oil Syndrome. We are indebted to Dr M. Studt and Dr E. Fernández-Alvarez, from the National Center for Organic Chemistry, C.S.I.C., for kindly providing the synthetic fatty acid anilides. We also wish to thank Prof. C. Gitler for helpful discussion.

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Marquet, A., Larraga, V., Diez, J.L. et al. Immunogenicity of fatty acid anilides in rabbits and the pathogenesis of the Spanish toxic oil syndrome. Experientia 40, 977–980 (1984). https://doi.org/10.1007/BF01946468

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  • DOI: https://doi.org/10.1007/BF01946468

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