Summary
The stimulatory effect of nitro-compounds on arterial and hepatic guanylate cyclase became significantly depressed at 0.2 μM and higher concentration of free Ca2+. The basal enzyme activity proved to be Ca2+-independent.
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References
Mittal, C. K., and Murad, F., Cyclic Nucleotides, Handbook exp. Pharmac. vol 58/I, p. 225. Eds J. W. Kebabian and J.A. Nathanson Springer, Berlin/Heidelberg/New York 1982.
Ignarro, L.J., Lippton, H., Edwards, J.C., Baricos, W.H., Hyman, A.L., Kadowitz, P.J., and Gruetter, C.A., J. Pharmac. exp. Ther.218 (1981) 739.
Gruetter, C.A., Barry, B.K., McNamara, D.B., Gruetter, D.Y., Kadowitz, P.J., and Ignarro, L.J., J. cyclic Nucleot. Res.5 (1979) 211.
Kimura, H., and Murad, F., J. biol. Chem.249 (1974) 6910.
Kimura, H., Mittal, C.K., and Murad, F., J. biol. Chem.251 (1976) 7769.
Chrisman, T.D., Garbers, D.L., Parks, M.A., and Hardman, J.G., J. biol. Chem.250 (1975) 374.
Criss, W.E., Murad, F., and Kimura, H., J. cyclic Nucleot. Res.2 (1976) 11.
Birnbaumer, L., Torres, H.N., Flawia, M.M., and Fricke, R.F., Analyt. Biochem.93 (1979) 124.
Piascik, M.T., Wisler, P.T., Johnson, C.L., and Potter, J.D., J. biol. Chem.255 (1980) 4176.
Kukovetz, W.R., Holzmann, S., Wurm, A., and Pöch, G., Naunyn-Schmiedeberg's Arch. Pharmac.310 (1979) 129.
Potter, J.D., Piascik, M.T., Wisler, P.L., Robertson, S.R., and Johnson, C.L., Ann. N.Y. Acad. Sci.356 (1980) 220.
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This study was supported by the Anton Dreher-Foundation for Medical Research.
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Steurer, G., Schütz, W. Guanylate cyclase stimulation by nitro-compounds is dependent on free Ca2+1 . Experientia 40, 970–971 (1984). https://doi.org/10.1007/BF01946463
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DOI: https://doi.org/10.1007/BF01946463