, Volume 40, Issue 9, pp 967–969 | Cite as

Genetic and histological aspects of stomach lesions induced by systemic injection of phenylbutazone in the rat

  • P. Driscoll
  • P. Kugler


Roman high-avoidance (RHA/Verh) rats, food-deprived (F-D) for 5 days, had higher stomach lesion scores than did F-D Roman low-avoidance (RLA/Verh) rats. F-D RLA/Verh rats which were injected i.p. with phenylbutazone (PBZ) 24 h before examination, however, had higher scores than did PBZ-treated, F-D RHA/-Verh rats. Histologically, extensive edema and cellular infiltration (including numerous erythrocytes) were seen below lesions, in the submucosa, denoting vascular damage. An attenuating influence of food on the ulcerogenic effects of PBZ, which were much more severe in F-D than in fed rats was also indicated.

Key words

Phenylbutazone stomach ulcers food-deprivation rats food-deprived stomach lesion scores ulcer susceptibility genetic differences in 


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  1. 2.
    Driscoll, P., and Bättig, K., in: Genetics of the Brain, p. 95. Ed. I. Lieblich. Elsevier Biomedical, Amsterdam 1982.Google Scholar
  2. 3.
    Driscoll, P., and Käsermann, H. P., Drug Res.27, (1977) 1582.Google Scholar
  3. 4.
    Martin, J. R., Overstreet, D. W., Driscoll, P., and Bättig, K., Psychopharmacology72, (1981) 135.Google Scholar
  4. 5.
    Jori, A., Pescador, R., and Pugliatti, C., Biochem. Pharmac.20 (1971) 2695.Google Scholar
  5. 6.
    Driscoll, P., Martin, J. R., Kugler, P., and Bättig, K., Physiol. Behav.31 (1983) 225.Google Scholar
  6. 7.
    Krainin, P., J. Am. med. Assoc.152 (1953) 31.Google Scholar
  7. 8.
    Raffensperger, E. C., J. Am. med. Assoc.152 (1953) 30.Google Scholar
  8. 9.
    Djahanguiri, B., Zarrindast, M. R., and Gerayesh-Nejad, S., Eur. J. Pharmac.51 (1978) 77.Google Scholar
  9. 10.
    Paré, W. P., Glavin, G. B., and Vincent, G. P., Physiol. Behav.19 (1977) 315.Google Scholar
  10. 11.
    Athey, G. R., and Iams, S. G., Life Si.28 (1981) 889.Google Scholar
  11. 12.
    Mikhail, A., and Hirschberg, J., Physiol. Behav.8 (1972) 769.Google Scholar
  12. 13.
    Paré, W. P., and Temple, L. J., Physiol. Behav.11 (1973) 371.Google Scholar
  13. 14.
    Cioli, V., Putzolu, S., Rossi, V., Scarza Barcellona, P., and Corradino, C., Toxic. appl. Pharmac.50 (1979) 283.Google Scholar
  14. 15.
    Glavin, G. B., and Mikhail, A. A., Physiol. Behav.17 (1976) 777.Google Scholar
  15. 16.
    Satoh, H., Guth, P. H., and Grossman, M. I., Gastroenterology83 (1982) 210.Google Scholar
  16. 17.
    Mersereau, W. A., and Hinchey, E. J., Am. J. Physiol.242 (1982) G429.Google Scholar
  17. 18.
    Robins, P. G., Br. J. exp. Path.61, (1980) 497.Google Scholar

Copyright information

© Birkhäuser Verlag 1984

Authors and Affiliations

  • P. Driscoll
    • 1
    • 2
  • P. Kugler
    • 1
    • 2
  1. 1.Faculté de Médecine, Institut d'AnatomieUniversité de LausanneLausanne(Switzerland)
  2. 2.Institut für VerhaltenswissenschaftEidg. Technische HochschuleZürich(Switzerland)

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