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Experientia

, Volume 40, Issue 9, pp 967–969 | Cite as

Genetic and histological aspects of stomach lesions induced by systemic injection of phenylbutazone in the rat

  • P. Driscoll
  • P. Kugler
Article

Summary

Roman high-avoidance (RHA/Verh) rats, food-deprived (F-D) for 5 days, had higher stomach lesion scores than did F-D Roman low-avoidance (RLA/Verh) rats. F-D RLA/Verh rats which were injected i.p. with phenylbutazone (PBZ) 24 h before examination, however, had higher scores than did PBZ-treated, F-D RHA/-Verh rats. Histologically, extensive edema and cellular infiltration (including numerous erythrocytes) were seen below lesions, in the submucosa, denoting vascular damage. An attenuating influence of food on the ulcerogenic effects of PBZ, which were much more severe in F-D than in fed rats was also indicated.

Key words

Phenylbutazone stomach ulcers food-deprivation rats food-deprived stomach lesion scores ulcer susceptibility genetic differences in 

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Copyright information

© Birkhäuser Verlag 1984

Authors and Affiliations

  • P. Driscoll
    • 1
    • 2
  • P. Kugler
    • 1
    • 2
  1. 1.Faculté de Médecine, Institut d'AnatomieUniversité de LausanneLausanne(Switzerland)
  2. 2.Institut für VerhaltenswissenschaftEidg. Technische HochschuleZürich(Switzerland)

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