Summary
Cyclic adenosine 3′,5′-monophosphate (cyclic AMP)-binding proteins which have the characteristics of cyclic AMP-dependent protein kinase (E.C. 2.7.1.37) regulatory subunits, have been identified in rat and human saliva. Concentration of these proteins was increased in rat saliva after stimulation with isoproterenol, suggesting that they were released during exocytosis. Cyclic AMP-dependent protein kinase catalytic activity was not measurable in saliva of either species.
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Schneyer, L.H., and Schneyer, C.A., Ann. N.Y. Acad. Sci.85 (1960) 189.
Young, J.A., and Schneyer, C.A., Aust. J. exp. Biol. Med.59 (1981) 1.
Oppenheim, F.G., Hay, D.I., and Franzblau, C., Biochemistry10 (1971) 4233.
Levine, M., and Keller, P.J., Archs oral Biol.22 (1977) 37.
Arneberg, P., Archs oral Biol.19 (1974) 921.
Iversen, J.M., Johnson, D.A., Kauffman, D.L., Keller, P.J., and Robinovitch, M.R., Archs oral Biol.27 (1982) 925.
Kuo, J.F., and Greengard, P., Proc. natl Acad. Sci. USA64 (1969) 1349.
Bechtel, P.J., Beavo, J.A., and Krebs, E.G., J. biol. Chem.252 (1976) 248.
Corbin, J.D., Keely, S.L., and Park, C.R., J. biol. Chem.250 (1975) 218.
Hoyer, P., Owens, J., and Haley, B., Ann. N.Y. Acad. Sci.346 (1980) 280.
Laemmli, U.K., Nature227 (1970) 680.
Lowry, O.H., Rosebrough, N.J., Farr, A.L., and Randall, R.J., J. biol. Chem.193 (1951) 265.
Hofman, F., Beavo, J.A., Bechtel, P.J., and Krebs, E.G., J. biol. Chem.250 (1975) 7795.
Dills, W.L., Beavo, J.A., Bechtel, P.J., and Krebs, E.G., Biochem. biophys. Res. Commun.62 (1975) 70.
Corbin, J.D., Sugden, P.H., West, L., Flockhart, D.A., Lincoln, T.M., and McCarthy, D., J. biol. Chem.253 (1978) 3997.
Mednieks, M.I. and Jungmann, R.A., Archs Biochem. Biophys.213 (1982) 128.
Mednieks, M.I., and Hand, A.R., Eur. J. Cell Biol.28 (1982) 264.
Schramm, M., and Selinger, Z., J. cyclic Nucleot. Res.1 (1975) 181.
Robinson-Steiner, A.M., and Corbin, J.D., J. biol. Chem.258 (1983) 1032.
Zick, S.K., and Taylor, S.S., J. biol. Chem.257 (1982) 2287.
Hayes, J.S., and Brunton, L.L., J. cyclic Nucleot. Res.8 (1982) 1.
Schmid, G., Hempel, K., Fricke, L., Wernge, H., and Heidland, A., Dt. med. Wschr.100 (1975) 1435.
Schaeffer, L.D., Sproles, A., and Krakowski, A., J. dent. Res.52 (1979) 629.
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Mednieks, M.I., Hand, A.R. Cyclic AMP binding proteins in saliva. Experientia 40, 945–947 (1984). https://doi.org/10.1007/BF01946451
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DOI: https://doi.org/10.1007/BF01946451