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Experientia

, Volume 42, Issue 11–12, pp 1302–1304 | Cite as

Naturally-occurring crystals of photocarcinogenic furocoumarins on the surface of parsnip roots sold as food

  • O. Ceska
  • S. Chaudhary
  • P. Warrington
  • G. Poulton
  • M. Ashwood-Smith
Short Communications

Summary

Normal levels of total furocoumarins in fresh parsnip roots are as high as 96 ppm (wet weight). In older ‘spoiled’ and diseased parsnips freely available in grocery stores these values may be increased by 2500%. So high are the amounts in some instances, that mixed crystals of furocoumarins can be detected on the surfaces of the parsnip roots by both conventional low powered microscopy and SEM. The principal crystal form was angelicin but the presence of psoralen, 5-MOP and 8-MOP was confirmed by HPLC, TLC, photobiological assay and analysis of mass spectra.

Key words

Parsnip furocoumarins photocarcinogenesis 5-methoxypsoralen 8-methoxypsoralen psoralen angelicin photosensitivity 

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References

  1. 1.
    Beier, R. C., Ivie, G. W., and Oertli, E. H., Am. chem. Soc. Symp. Ser. (4)SRCL 234 (1983) 295.Google Scholar
  2. 2.
    Beier, R. C., and Oertli, E. H., Phytochemistry22 (1983) 2595.Google Scholar
  3. 3.
    Ashwood-Smith, M. J., and Grant, E., Experientia33 (1977) 384.Google Scholar
  4. 4.
    Ashwood-Smith, M. J., Poulton, G. A., Barker, M., and Mildenberger, M., Nature285 (1980) 407.Google Scholar
  5. 5.
    Ashwood-Smith, M. J., Nataraja, A. T., and Poulton, G. A., J. natn. Canc. Inst.69 (1982) 189.Google Scholar
  6. 6.
    Zajdela, F., and Bisangni, E., Carcinogenesis2 (1981) 121.Google Scholar
  7. 7.
    Griffin, A. C., Hakim, R. E., and Knox, J., J. Invest. Derm.31 (1958) 289.Google Scholar
  8. 8.
    Stern, R. S., Thibodeau, L. A., Kleinerman, R. A., N. Engl. J. Med.300 (1979) 809.Google Scholar
  9. 9.
    IARC Monograph on the evaluations of the carcinogenic risk of chemicals to humans. Suppl. 4, chemical, industrial processes and industries associated with cancer in humans, vol. 1–29. IARC, Lyon 1982.Google Scholar
  10. 10.
    Ashwood-Smith, M. J., Ceska, O., and Chaudhary, S. K., Br. Med. J.290 (1985) 1249.Google Scholar
  11. 11.
    Ivie, G. W., Holt, D. L., and Ivey, M. C., Science213 (1981) 909.Google Scholar
  12. 12.
    Ames, B. N., Science221 (1983) 1256.Google Scholar
  13. 13.
    Mitchell, J., and Rook, A., in: Botanical Dermatology, Greengrass, Vancouver 1979.Google Scholar
  14. 14.
    Chaudhary, S. K., Ceska, O., Warrington, P. J., and Ashwood-Smith, M. J., J. Agric. Food Chem.33 (1985) 1153.Google Scholar
  15. 15.
    Ceska, O., Chaudhary, S. K., Warrington, P. J., and Ashwood-Smith, M. J., Phytochemistry25 (1986) 81.Google Scholar
  16. 16.
    Ashwood-Smith, M. J., Poulton, G. A., Ceska, O., Liu, M., and Furniss, E., Photochem. Photobiol.38 (1983) 113.Google Scholar
  17. 17.
    Johnson, C., Brannon, D. R., and Kuc, J., Phytochemistry12 (1973) 2961.Google Scholar
  18. 18.
    Phytophotodermatitis among Grocery Workers. J. Am. Med. Ass.253 (1985) 753.Google Scholar
  19. 19.
    Hannwalt, P. C., Kaye, J., Smith, C. A., and Zolan, M., in: Psoralens in Cosmetics and Dermatology, p. 133. Eds. J. Cahn, P. Forlot, C. Grupper, A. Maybeck and F. Urbach. Pergamon, Oxford 1982.Google Scholar
  20. 20.
    Ben-Hur, E., and Song, P.-S., Adv. Radiat. Biol. II (1984) 131.Google Scholar

Copyright information

© Birkhäuser Verlag 1986

Authors and Affiliations

  • O. Ceska
    • 1
  • S. Chaudhary
    • 1
  • P. Warrington
    • 1
  • G. Poulton
    • 2
  • M. Ashwood-Smith
    • 1
  1. 1.Department of BiologyUniversity of VictoriaVictoriaCanada
  2. 2.Department of ChemistryUniversity of VictoriaVictoriaCanada

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