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Experientia

, Volume 42, Issue 11–12, pp 1247–1249 | Cite as

Hypoaldosteronism in piglets induced by carbadox

  • E. J. van der Molen
  • G. J. de Graaf
  • Th. J. Spierenburg
  • M. J. A. Nabuurs
  • A. J. Baars
  • L. P. Jager
Short Communications

Summary

An exploratory study was made of the mechanisms underlying the toxic action of carbadox in young pigs: dehydration, loss of appetite and at autopsy seemingly specific and selective structural alterations of the glomerular zone of the adrenal cortex. Administration of carbadox in the feed, in dosages of 150 ppm (approximately 6 mg·kg−1 b.wt·day−1) caused a rapid decline in the plasma aldosterone levels (to 10% of control) followed by significant changes in the sodium and potassium levels in blood. Characteristic for the toxic action of carbadox are the rapid and seemingly selective and specific alterations in the aldosterone-releasing zona glomerulosa of the adrenals. Our results indicate that with carbadox a functional and possibly reversible extirpation of the adrenal zona glomerulosa can be achieved in pigs.

Key words

Carbadox aldosterone adrenal damage zona glomerulosa electrolyte homeostasis pig 

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References

  1. 2.
    Molen, E. J. van der, Nabuurs, M. J. A., and Jager, L. P., Zentbl. VetMed. A32 (1985) 540.Google Scholar
  2. 3.
    Guyton, A. C., Textbook of Medical Physiology, 5th edn, p. 435. Saunders, Philadelphia 1981.Google Scholar
  3. 4.
    Guyton, A. C., Textbook of Medical Physiology, 5th edn, p. 944. Saunders, Philadelphia 1981.Google Scholar
  4. 5.
    Wenting, G. J., Man In't Veld, A. J., Woittiez, A. J., Boomsa, F., Laird-Meeter, K., Simoons, M. L., Hugenholtz, P. G., and Schalekamp, M. A. D. H., Br. Heart J.49 (1983) 65.Google Scholar
  5. 6.
    Bayard, F., Cooke, C. R., Tiller, D. J., Beitins, I. Z., Kowarski, A., Walker, W. G., and Migeon, C. J., J. clin. Invest.50 (1971) 1585.Google Scholar
  6. 7.
    Giurgea, R., Borsa, M., and Ilyœs, I., Archs exp. vet. Med.30 (1976) 861.Google Scholar
  7. 8.
    Pfizer, Technical Report No. 8307. Pfizer Int. Inc., New York 1983.Google Scholar

Copyright information

© Birkhäuser Verlag 1986

Authors and Affiliations

  • E. J. van der Molen
    • 1
  • G. J. de Graaf
    • 1
  • Th. J. Spierenburg
    • 1
  • M. J. A. Nabuurs
    • 1
  • A. J. Baars
    • 1
  • L. P. Jager
    • 1
  1. 1.CDICentral Veterinary InstituteLelystad(The Netherlands)

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