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Ascorbic acid: Effect of high doses on brain and heart catecholamine levels in guinea-pigs and rats

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Zusammenfassung

Längerdauernde Zufuhr hoher Dosen von Ascorbinsäure (1000 mg/kg) senkt bei Meerschweinchen, nicht aber bei Ratten, den Noradrenalin-Spiegel im Herzen signifikant. Hingegen wird bei beiden Tierspezies der Noradrenalin-Spiegel im Hirn nicht verändert.

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References

  1. L. Pauling, Science160, 265 (1968).

    Article  CAS  Google Scholar 

  2. W. L. Dalton, J. Indiana State med. Ass.55, 1151 (1962).

    CAS  Google Scholar 

  3. M. L. Ruccitelli, J. Am. geriat. Soc.20, 34 (1972).

    Article  Google Scholar 

  4. L. Pauling,Vitamin C and the Common Cold (W. H. Freeman Co., San Francisco, California 1970).

    Google Scholar 

  5. N. B. Thoa, R. J. Wurtman andJ. Axelrod, Proc. Soc. exp. Biol. Med.121, 267 (1965).

    Article  Google Scholar 

  6. O. A. Lokoshko andL. D. Lesnykh, Ukr. Biokhem. Zh.43, 539 (1971).

    Google Scholar 

  7. W. D. Horst andJ. Jester, Biochem. Pharmac.20, 2633 (1971).

    Article  CAS  Google Scholar 

  8. R. Laverty andD. F. Sharman, Br. J. Pharmac.24, 538 (1965).

    CAS  Google Scholar 

  9. J. H. Roe andC. A. Kuether, J. biol. Chem.147, 399 (1943).

    Article  CAS  Google Scholar 

  10. J. A. Izquierdo andI. J. Jofre, J. Pharm. Pharmac.17, 391 (1965).

    Article  CAS  Google Scholar 

  11. W. D. Horst, I. J. Kopin andE. R. Ramey, Am. J. Physiol.215, 817 (1968).

    Article  CAS  Google Scholar 

  12. A. Askari, M. Frey, J. R. Pitts andS. N. Rao, 5th Int. Congress Pharm. (San Fransisco, California, 1972) Abstracts of Volunteer Papers, p. 11.

  13. The authors wish to thank Mr.G. Matusik and Mrs.Halyna Holowaschenko for excellent technical assistance and Mrs.Margaret Althoff for her assistance in the preparation of the manuscript.

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Authors and Affiliations

  1. Research Division, Hoffmann-La Roche Inc., 07110, Nutley, New Jersey, USA

    T. Dashman, D. Horst, G. Bautz & J. J. Kamm

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  1. T. Dashman
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  2. D. Horst
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  3. G. Bautz
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  4. J. J. Kamm
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Dashman, T., Horst, D., Bautz, G. et al. Ascorbic acid: Effect of high doses on brain and heart catecholamine levels in guinea-pigs and rats. Experientia 29, 832–833 (1973). https://doi.org/10.1007/BF01946316

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