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Carcinostatic activity of a thiazolidinonylidene-hydrazonothiazolidinone derivative against DMBA-induced mammary carcinomata in female Sprague-Dawley rats

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Zusammenfassung

5-Methyl-3-(2-methylallyl)-2-[(3-methyl-4-oxo-2-thiazolidinyliden)-hydrazono]-4-thiazolidinon erwies sich bei guter therapeutischer Breite als stark karzinostatisch wirksam bei DMBA-induzierten Mamma-Karzinomen weiblicher Sprague-Dawley Ratten. Eine geringere chemotherapeutische Wirkung fand sich auch bei Walker CaSa 256, DMBA-induzierten Hautkarzinomen und Ehrlich Ascites Karzinom.

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References

  1. Ch. Huggins, L. C. Grand andF. P. Brillantes, Nature, Lond.189, 204 (1961).

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  2. No placebo-treated control group was included in these experiments, since the vehicle used for the suspension of GP 48 989 had previously been shown to be indifferent.

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Authors and Affiliations

  1. Research Laboratories of the Pharmaceuticals Divisions of CIBA-GEIGY Ltd., CH-4002, Basel, Switzerland

    K. H. Schmidt-Ruppin, A. Meisels, E. Schott, A. Storni & K. Schieweck

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  1. K. H. Schmidt-Ruppin
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  2. A. Meisels
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  3. E. Schott
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  4. A. Storni
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  5. K. Schieweck
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Schmidt-Ruppin, K.H., Meisels, A., Schott, E. et al. Carcinostatic activity of a thiazolidinonylidene-hydrazonothiazolidinone derivative against DMBA-induced mammary carcinomata in female Sprague-Dawley rats. Experientia 29, 823–825 (1973). https://doi.org/10.1007/BF01946310

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  • DOI: https://doi.org/10.1007/BF01946310

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