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Saccharin preference of butyraldoxime-treated C57BL mice

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Zusammenfassung

Butyraldoxim, das in C57BL-Mäusen bevorzugtes Alkoholtrinken vermindert, wurde im 2-Wahl-Vorzugsversuch in Wasser oder Saccharinlösung verabreicht und führte zu keiner konditionierten Aversion. Das Ergebnis bestätigt die Hypothese, der Butyraldoxim-Effekt beruhe auf spezifisch metabolischer Wechselwirkung mit Alkohol.

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Literatur

  1. B. K. Koe andS. S. Tenen, Fedn. Proc.28, 546 (1969).

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  2. B. K. Koe andS. S. Tenen, J. Pharmac. exp. Ther.174, 434 (1970).

    Google Scholar 

  3. E. S. Perman, Acta physiol. scand.55, Suppl.190, 5 (1962).

    Google Scholar 

  4. M. Nachman, D. Lester andJ. Le Magnen, Science168, 1244 (1970).

    Google Scholar 

  5. J. A. Farley, W. A. McLaurin, B. B. Scarborough andT. D. Rawlings, Psychol. Rep.14, 491 (1964).

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  6. Butyraldoxime was also administered for 14 days in the ethanol studies1,2. In those studies a concentration of only 0.6 mg/ml was able to produce an alteration in ethanol preference. In the present saccharin study we increased the drug concentration in order to insure obtaining any possible conditioned aversive effects.

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Authors and Affiliations

  1. Department of Pharmacology, Pfizer Inc, 06340, Groton, Connecticut, USA

    S. S. Tenen & B. K. Koe

Authors
  1. S. S. Tenen
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  2. B. K. Koe
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Tenen, S.S., Koe, B.K. Saccharin preference of butyraldoxime-treated C57BL mice. Experientia 28, 1194–1195 (1972). https://doi.org/10.1007/BF01946165

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  • DOI: https://doi.org/10.1007/BF01946165

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