Experientia

, Volume 33, Issue 8, pp 1079–1080 | Cite as

Metabolic rearrangement of fluorenone oxime to phenanthridinone

  • L. Sternson
  • F. Hincal
Specialia Pharmacologica

Summary

Fluorenone oxime is metabolized in vivo in the rat to phenanthridinone which is excreted in the urine. The structure of the metabolite has been determined by comparison of chromatographic and spectral properties of the metabolites with authentic phenathridinone.

Keywords

Oxime Spectral Property Fluorenone Phenanthridinone Metabolic Rearrangement 

References

  1. 2.
    H. B. Hucker, B. M. Michniewicz and R. E. Rhodes, Biochem. Pharmac.20, 2123 (1971).CrossRefGoogle Scholar
  2. 3.
    R. W. Fuller, C. J. Parli and B. B. Molloy, Biochem. Pharmac.22, 2059 (1973).CrossRefGoogle Scholar
  3. 4.
    C. J. Parli and R. E. McMahon, Drug Metab. Disp.1, 337 (1973).Google Scholar
  4. 5.
    H. B. Hucker, Drug Metab. Disp.1, 332 (1973).Google Scholar
  5. 6.
    J. Hes and L. A. Sternson, Drug Metab. Disp.2, 345 (1974).Google Scholar
  6. 7.
    L. A. Sternson and J. Hes, Pharmacology13, 234 (1975).PubMedGoogle Scholar
  7. 8.
    L. Guy Donaruma and W. Z. Heldt, Org. React.11, 1 (1960).Google Scholar
  8. 9.
    C. C. Irving, Xenobiotica1, 387 (1971).PubMedGoogle Scholar
  9. 10.
    T. S. Stevens and W. E. Watts, in: Selected Molecular Rearrangements, p. 52. Van Nostrand Reinhold Co., London 1973.Google Scholar
  10. 11.
    H. Pan and T. L. Fletcher, J. med. Chem.12, 822 (1969).CrossRefPubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag 1977

Authors and Affiliations

  • L. Sternson
    • 1
  • F. Hincal
    • 1
  1. 1.Department of Pharmaceutical ChemistryUniversity of KansasLawrenceUSA

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