Summary
4000 rads of mixed gamma neutron radiation administered to rhesus monkeys released a significant amount of histamine into their circulation. When the monkeys were treated with a mast-cell histamine depleter (compound 48/80) for 4 days and then irradiated, no increase in circulating histamine was seen. When 48/80 was given 20 min after irradiation, only a slight increase in histamine was seen, indicating that 4000 rads had released most of the mast-cell histamine.
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Doyle, T.F., Strike, T.A. Radiation-released histamine in the rhesus monkey as modified by mast-cell depletion and antihistamine. Experientia 33, 1047–1049 (1977). https://doi.org/10.1007/BF01945962
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DOI: https://doi.org/10.1007/BF01945962