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Synthesis of (Glu-OMe)2-litorin

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  • Chimica, Biochimica
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Summary

The synthesis of the nonapeptide<Glu-Glu(OMe)-Trp-Ala-Val-Gly-His-Phe-Met-NH2, corresponding to the formula of the (Glu-OMe)2-litorin, is described. The compound has the same chemical and biological properties of the second bombesin-like peptide extracted from the skin of the Australian frog Litoria aurea.

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References

  1. The amino acids used, with the exception of glycine, have the L-configuration. Symbols and abbreviations are in accordance with the recommendations of the IUPAC-IUB Commission on Biochemical Nomenclature, Biochemistry11, 1726 (1972).

  2. A. Anastasi, P. Montecucchi, F. Angelucci, V. Erspamer and R. Endean, Experientia, in press (1977).

  3. W. König, and R. Geiger, Chem. Ber.103, 788 (1970).

    Article  PubMed  Google Scholar 

  4. T. Fujii, T. Kimura and S. Sakakibara, Bull. chem. Soc. Japan49, 1595 (1976)

    Article  CAS  Google Scholar 

  5. Paper electrophoretic mobilities in HCOOH/CH3COOH/H2O (615∶500∶3885) and in CH3COOH/pyridine/H2O (50∶450∶4500), respectively, with histidine as standard.

  6. J. Honzl and J. Rudinger, Coll. Czech. chem. Commun.26, 2333 (1961).

    Article  CAS  Google Scholar 

  7. We are indebted to dr. A. Anastasi and to prof. V. Erspamer for these assays.

  8. T. Fujii and S. Sakakibara, Bull. chem. Soc. Japan47, 3146 (1974).

    Article  CAS  Google Scholar 

  9. F. Angelucci and R. de Castiglione, Experientia31, 507 (1975).

    Article  CAS  Google Scholar 

  10. J. Beacham, G. Dupuis, F. M. Finn, H. T. Storey, C. Yanaihara, N. Yanaihara and K. Hoffmann, J. Am. chem. Soc.93, 5526 (1971).

    Article  CAS  PubMed  Google Scholar 

  11. G. Losse, H. Jesehkeit and W. Langenbeck, Chem. Ber.96, 204 (1963).

    Article  CAS  Google Scholar 

  12. E. Schröder and E. Klieger, Justus Liebigs Ann. Chem.673, 196 (1964).

    Article  Google Scholar 

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Authors and Affiliations

  1. Laboratori Ricerche Farmitalia, I-20146, Milano, Italy

    M. Mazzoli & R. de Castiglione

Authors
  1. M. Mazzoli
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  2. R. de Castiglione
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Mazzoli, M., de Castiglione, R. Synthesis of (Glu-OMe)2-litorin. Experientia 33, 990–991 (1977). https://doi.org/10.1007/BF01945923

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  • DOI: https://doi.org/10.1007/BF01945923

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