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Experientia

, Volume 31, Issue 11, pp 1366–1367 | Cite as

Effect of progesterone on human corticosteroid 21-hydroxylation

  • R. H. Wickramasinghe
  • G. T. Bryan
Specialia Endocrinologica

Summary

Progesterone inhibits the 21-hydroxylation of 17α-hydroxyprogesterone by human adrenal cortex microsomes. The possible light this finding may shed on the genetic condition, the ‘adrenogenital syndrome’ is discussed.Km and V max data for the above hydroxylation reaction are given.

Keywords

Corticosteroid Progesterone Adrenal Cortex Genetic Condition Hydroxylation Reaction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag 1975

Authors and Affiliations

  • R. H. Wickramasinghe
    • 1
    • 2
  • G. T. Bryan
    • 1
    • 2
  1. 1.Pediatric Endocrine Laboratory, Department of PediatricsThe University of Texas Medical BranchGalvestoneUSA
  2. 2.Clinical Study CenterThe University of Texas Medical BranchGalvestoneUSA

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