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Lysosomal membrane fragility and catabolism of cytosolic proteins: evidence for a direct relationship

Experientia volume 43, pages 320–323 (1987)Cite this article

Summary

A direct relationship was established between the stability of the lysosomal membrane and an estimate of cytosolic protein catabolism, based on loss of radiolabel from prelabeled protein. Lysosomes in the lysosomally-rich digestive cells of the midgut gland of the marine mussel (Mytilus edulis) were destabilized by experimental treatment with phenanthrene.

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Affiliations

  1. Natural Environment Research Council, Institute for Marine Environmental Research, Prospect Place, PL1 3DH, The Hoe, Plymouth, England

    M. N. Moore

  2. Istituto di Fisiologia Generale, Universita di Genova, Palazzo delle Scienze, Corso Europa, Genova, Italy

    A. Viarengo

Authors
  1. M. N. Moore
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  2. A. Viarengo
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Moore, M.N., Viarengo, A. Lysosomal membrane fragility and catabolism of cytosolic proteins: evidence for a direct relationship. Experientia 43, 320–323 (1987). https://doi.org/10.1007/BF01945568

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  • DOI: https://doi.org/10.1007/BF01945568

Key words

  • Lysosomes
  • lysosomal stability
  • protein catabolism
  • digestive cells
  • marine mussel
  • phenanthrene