Summary
A general update review of the dynamic aspect of protein metabolism is presented. The effect of excess protein level on protein metabolism has been the object of a limited number of studies in man. From the information available, it appears that the primary regulatory pathway for body protein homeostasis is the process of amino acid (protein) oxidation.
Similar content being viewed by others
References
Borsook, H., and Kieghley, G. L., The ‘continuing’ metabolism of nitrogen in animals. Proc. Roy. Soc. (London) Ser. B118 (1935) 488.
Fern, E. B., Garlick, P. J., McNurlan, M. A., and Waterlow, J. C., The excretion of isotope in urea and ammonia for estimating protein turnover in man with (N-15) glycine. Clin. Sci.61 (1981) 217–228.
Jéquier, E., and Schutz, Y., Long-term measurements of energy expenditure in humans using a respiration chamber. Am. J. clin. Nutr.38 (1983) 989–998.
Kang-Lee, Y. A., and Harper, A. E., Threonine metabolism in vivo: effect of threonine intake and prior induction of threonine dehydratase in rats. J. Nutr.108 (1978) 163–175.
Millward, D. J., and Rivers, J. P. W., The nutritional role of indispensable amino acids and the metabolic basis for their requirements. Eur. J. clin. Nutr.42 (1988) 367–393.
Millward, D. J., Jackson, A. A., Price, G., and Rivers, J. P. W., Human amino acid and protein requirements: Current dilemmas and uncertainties. Nutr. Res. Rev.2 (1989) 109–132.
Munro, H. N., in: The Liver: Biology and Pathology, pp. 677–691. Eds I. M. Arias, H. Popper and D. Schachter et al. Raven Press, New York 1982.
Oddoye, E. A., and Margen, S., Nitrogen balance studies in humans: long-term effect of high nitrogen intake on nitrogen accretion. J. Nutr.109 (1979) 363–377.
Parizkova, J., Age-dependent changes in dietary intake related to work output, physical fitness, and body composition. Am. J. clin. Nutr.49 (1989) 962–967.
Reeds, P. J., and Garlick, P. J., Nutrition and protein turnover in man. Adv. Nutr. Res.6 (1984) 93–138.
Robinson, S. M., Jaccard, C., Persaud, C., Jackson, A. A., Jéquier, E., and Schutz, Y., Protein turnover and thermogenesis in response to high-protein and high-carbohydrate feeding in men. Am. J. clin. Nutr.52 (1990) 72–80.
Schoenheimer, R., The Dynamic State of Body Constituents. Harvard University Press, Cambridge, Massachusetts 1942.
Waterlow, J. C., Garlick, P. J., and Millward, D. J., Protein Turnover in Mammalian Tissues and in the Whole Body. North Holland Publishing Company, Amsterdam/New York/Oxford 1978.
Waterlow, J. C., Methods of measuring protein turnover, in: Nitrogen Metabolism in Man, pp. 279. Eds J. C. Waterlow and J. M. L. Stephen. Applied Science Publishers, London/New Jersey 1981.
Waterlow, J. C., Metabolic adaptation to low intakes of energy and protein. A. Rev. Nutr.6 (1986) 495–526.
WHO (World Health Organization). Energy and Protein Requirements. Report of a joint FAO(WHO/UNU) Expert Consultation. Technical Report Series 724. World Health Organization, Geneva 1985.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Fern, E.B., Bielinski, R.N. & Schutz, Y. Effects of exaggerated amino acid and protein supply in man. Experientia 47, 168–172 (1991). https://doi.org/10.1007/BF01945420
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01945420