Experientia

, Volume 30, Issue 11, pp 1356–1357 | Cite as

Stimulation and suppression of somatomedin activity by serotonin and melatonin

  • G. A. Smythe
  • Margaret C. Stuart
  • L. Lazarus
Endocrinologica

Keywords

Growth Hormone Serotonin Melatonin Prolactin Sulpiride 

Résumé

La sérotonine et sa dérivée, la mélatonine, hormones de la glande pinéale, ont les effets tr⪻s significatifs mais opposés sur l'activité de la somatomédine. L'addition de la sérotomine au sérum normal a fait augmenter l'activité de la somatomédine de 0.952±0.029 unités/ml à 1.265±0.073 unités/ml (p<0.005) tandis que l'addition de la mélatonine l'a abaissée à 0.652±0.091 (p<0.005).

Literatur

  1. 1.
    G. A. Smythe andL. Lazarus, Hormone Metab. Res.5, 227 (1973).CrossRefGoogle Scholar
  2. 2.
    G. A. Smythe andL. Lazarus, Nature, Lond.244, 230 (1973).CrossRefGoogle Scholar
  3. 3.
    G. A. Smythe andL. Lazarus, J. clin. Invest.,54, 116 (1974).CrossRefPubMedPubMedCentralGoogle Scholar
  4. 4.
    W. D. Salmon andW. H. Daughaday, J. Lab. clin. Med.49, 825 (1957).PubMedGoogle Scholar
  5. 5.
    W. H. Daughaday, K. Hall, M. S. Raben, W. D. Salmon, J. L. Van den Brande andJ. J. Van Wyk, Nature, Lond.235, 107 (1972).CrossRefGoogle Scholar
  6. 6.
    W. H. Daughaday andC. Reeder, J. Lab. clin. Med.68, 357 (1967).Google Scholar
  7. 7.
    J. J. van Wyk, K. Hall, J. L. van den Brande andR. P. Weaver, J. clin. Endocr.32, 389 (1971).CrossRefPubMedGoogle Scholar
  8. 8.
    P. R. Mann, Nature, Lond.216, 715 (1967).CrossRefGoogle Scholar
  9. 9.
    R. J. Boucek andT. R. Alvarez, Science167, 898 (1970).CrossRefPubMedGoogle Scholar
  10. 10.
    J. Kobayashi, T. Yoshizaki, T. Kitajima andF. Kawamura, Tokushima J. exp. Med.12, 45 (1965).PubMedGoogle Scholar
  11. 11.
    H. Laborit, J. M. Jouany andP. Niaussat, C. r. Soc. Biol., Paris153, 549 (1969).Google Scholar
  12. 12.
    A. Sirek, E. Geerling andO. V. Sirek, Am. J. Physiol.211, 1018 (1966).PubMedGoogle Scholar
  13. 13.
    W. B. Essman, S. Sherman andL. Kolodny, New Engl. J. Med.289, 870 (1973).Google Scholar
  14. 14.
    G. A. Smythe, J. F. Brandstater andL. Lazarus, in preparation.Google Scholar
  15. 15.
    F. Cattabeni, S. H. Koslow andE. Costa, Science178, 166 (1972).CrossRefPubMedGoogle Scholar
  16. 16.
    H. Yde, Acta endocr., Copenh.57, 557 (1968).Google Scholar

Copyright information

© Birkhäuser Verlag 1974

Authors and Affiliations

  • G. A. Smythe
    • 1
  • Margaret C. Stuart
    • 1
  • L. Lazarus
    • 1
  1. 1.Garvan Institute of Medical Research St. Vincent's HospitalSydneyAustralia

Personalised recommendations