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Effects of known and suspected neurotransmitter substances and of some nucleotides on isolated mast cells

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Résumé

Des suspensions de mastocytes péritoneaux isolées de rat furent incubées avec 10 substances différentes, connues ou presumées être des neurotransmitteurs. Seulement l'adenos ine triphosphate (ATP) aux concentrations supérieures à 2.64×10−6 M causèrent la dégranulation des mastocytes. L'ATP cause également la dégranulation des mastocytes dans le mésentère. L'action de l'ATP peut être responsible de la dégranulation des mastocytes cutanées observée après la stimulation antidromique des nerfs sensorieux, alors que de l'ATP est libéré dans la peau.

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  23. The technical assistance of MissChristine Golding and MissJo Mallon is gratefully acknowledged. The summary was kindly translated by Dr.J. Papaioannou. Most of the work was carried out during the tenure by the author of a Stanley Elmore Senior Research Fellowship of Sidney Sussex College, Cambridge.

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  1. Department of Anatomy, University of Cambridge, Downing Street, Cambridge, England

    J. A. Kiernan

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  1. J. A. Kiernan
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Kiernan, J.A. Effects of known and suspected neurotransmitter substances and of some nucleotides on isolated mast cells. Experientia 28, 653–655 (1972). https://doi.org/10.1007/BF01944958

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