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The proposal of an unified model for the interpretation of the activity of different classes ofβ-adrenergic agents

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Zusammenfassung

Mittels Röntgenstrahlen wurde die Kristallstruktur des β-Blockers Propranolol und seines Chlorhydrats vermessen und beim letzteren geweisse Unterschiede zu früheren Resultaten gefunden. Auf Grund dieser Vermessungen wird erklärt, weshalb auch der Typus B Antagonisten liefern kann, und eine neue Hypothese für die Wirksamkeit von Typ B aufgestellt.

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References

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Authors and Affiliations

  1. Department of Chemistry, University of Maryland, 20742, College Park, Maryland, USA

    H. L. Ammon, A. Balsamo, B. Macchia, F. Macchia, Donna-Beth Howe & W. E. Keefe

  2. Instituti di Chimica Farmaceutica e di Chimica Organica, Università di Pisa, 56100, Pisa, Italy

    H. L. Ammon, A. Balsamo, B. Macchia, F. Macchia, Donna-Beth Howe & W. E. Keefe

  3. Department of Biophysics, Medical College of Virginia, 23219, Richmond, Virginia, USA

    H. L. Ammon, A. Balsamo, B. Macchia, F. Macchia, Donna-Beth Howe & W. E. Keefe

Authors
  1. H. L. Ammon
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  2. A. Balsamo
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  3. B. Macchia
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  4. F. Macchia
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  5. Donna-Beth Howe
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  6. W. E. Keefe
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Additional information

We thank the University of Maryland Computer Science Center for a grant of computer time.

University of Maryland

Università di Pisa

Medical College of Virginia.

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Ammon, H.L., Balsamo, A., Macchia, B. et al. The proposal of an unified model for the interpretation of the activity of different classes ofβ-adrenergic agents. Experientia 31, 644–646 (1975). https://doi.org/10.1007/BF01944605

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  • DOI: https://doi.org/10.1007/BF01944605

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