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Experientia

, Volume 38, Issue 1, pp 132–134 | Cite as

Effect of azimexon (BM 12.531) on mouse granulocyte-macrophage and monocyte-macrophage progenitor cells

  • J. C. Jeng
  • K. F. McCarthy
  • M. A. Chirigos
  • J. F. Weiss
Article

Summary

Treatment of mice with 25 mg/kg azimexon (BM 12.531) resulted in an increase in granulocyte-macrophage colony-forming cells (GM-CFC) in spleen and bone marrow after a transient depression in the cell populations. Bone marrow monocyte-macrophage colony-forming cells (MM-CFC) increased at 7 days after treatment, and splenic MM-CFC were least affected by azimexon treatment. The increase in granulocytic and monocytic colony-forming cells may play a role in the previously reported protection by azimexon against radiation and drug-induced toxicity.

Keywords

Radiation Toxicity Bone Marrow Depression Cell Population 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag 1982

Authors and Affiliations

  • J. C. Jeng
    • 1
    • 2
  • K. F. McCarthy
    • 1
    • 2
  • M. A. Chirigos
    • 1
    • 2
  • J. F. Weiss
    • 1
    • 2
  1. 1.Biochemistry DepartmentArmed Forces Radiobiology Research InstituteBethesdaUSA
  2. 2.Laboratory of Chemical PharmacologyNational Institutes of HealthBethesdaUSA

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