Experientia

, Volume 38, Issue 1, pp 116–117 | Cite as

Effect of 15(R)-15-methyl-prostaglandin E2 on iron absorption in the rat

  • A. Gutnisky
  • P. Glikman
  • M. F. Gimeno
  • A. L. Gimeno
Article

Summary

The administration of 15(R)-15-methyl prostaglandin E2 (15(R)-15-M-PGE2) in vivo significantly diminished the uptake of59Fe into blood, spleen, liver, femur and dried intestine of rats, whereas acetylsalicylic acid (ASA) increased the counts significantly. This effect of ASA was counteracted by 15(R)-15-M-PGE2. It is suggested that prostaglandins (PGs) might play an important role in inhibiting iron absorption at the intestinal level.

Keywords

Iron Methyl Prostaglandin Iron Absorption Acetylsalicylic Acid 

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Copyright information

© Birkhäuser Verlag 1982

Authors and Affiliations

  • A. Gutnisky
    • 1
  • P. Glikman
    • 1
  • M. F. Gimeno
    • 1
  • A. L. Gimeno
    • 1
  1. 1.Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN)Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) de la República ArgentinaBuenos Aires(Argentina)

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