Effect of 15(R)-15-methyl-prostaglandin E2 on iron absorption in the rat
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The administration of 15(R)-15-methyl prostaglandin E2 (15(R)-15-M-PGE2) in vivo significantly diminished the uptake of59Fe into blood, spleen, liver, femur and dried intestine of rats, whereas acetylsalicylic acid (ASA) increased the counts significantly. This effect of ASA was counteracted by 15(R)-15-M-PGE2. It is suggested that prostaglandins (PGs) might play an important role in inhibiting iron absorption at the intestinal level.
KeywordsIron Methyl Prostaglandin Iron Absorption Acetylsalicylic Acid
- 8.H.C. Heinrich, in: Intestinal Iron Absorption, Methods of Measurement, Dose Relationship, Diagnostic and Therapeutic Application, Iron Deficiency p. 213. Academic Press, London/New York 1970.Google Scholar
- 10.A. Gutnisky, E. Speziale, M.F. Gimeno and A.L. Gimeno, Acta physiol. latinoam.30, 217 (1980).Google Scholar
- 11.P. Glikman, A. Gutnisky, M.F. Gimeno and A.L. Gimeno, Experientia37, 589 (1981).Google Scholar
- 12.R.J. Flower, Pharmac. Rev.26, 33 (1974).Google Scholar