Experientia

, Volume 33, Issue 6, pp 767–769 | Cite as

A haemagglutinin in the tissue fluid of the Pacific oyster, Crassostrea gigas, with specificity for sialic acid residues in glycoproteins

  • S. W. Hardy
  • P. T. Grant
  • Thelma C. Fletcher
Article

Summary

An agglutinin for human red cells has a specificity for sialic acid and a high affinity for bovine salivary glycoprotein. Digestion of the glycoprotein with Pronase or neuraminidase indicated that binding of sialic acid to receptors in the agglutinin is the first tepp in the mechanism of formation of a stable complex between ligand and receptor.

Keywords

Sialic Acid Stable Complex Pacific Oyster Tepp Tissue Fluid 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 2.
    H. Lis and N. Sharon, Ann. Rev. Biochem.42, 541 (1973).Google Scholar
  2. 3.
    S. Toyshima, M. Fukuda and T. Osawa, Biochemistry11, 4000 (1972).Google Scholar
  3. 4.
    A. C. Roche, R. Schauer and M. Monsigny, FEBS Letters,57, 245 (1975).Google Scholar
  4. 5.
    R. Carubelli, V. P. Bhavanandan and A. Gottschalk, Biochim. biophys. Acta101, 67 (1965).Google Scholar
  5. 6.
    D. Aminoff, Biochem. J.81, 384 (1961).Google Scholar
  6. 7.
    A. Gottschalk, A. S. Bhargava and V. L. N. Murty, in: Glycoproteins, vol. 5, part B, p. 810. Ed. A. Gottschalk. Elsevier, London 1972.Google Scholar
  7. 8.
    R. Schauer, H. P. Buscher and J. Casals-Stenzel, Biochem. Soc. Symp.40, 87 (1974).Google Scholar
  8. 9.
    J. Monod, J. C. Wyman and J. P. Changeux, J. mol. Biol.12, 81 (1965).Google Scholar
  9. 10.
    D. E. Koshland, jr, G. Nemethy and D. Fulmer, Biochemistry5, 365 (1966).Google Scholar
  10. 11.
    I. Singh, J. Physiol.92, 62 (1938).Google Scholar
  11. 12.
    R. H. Turner and I. E. Leiner, Analyt. Biochem.68, 651 (1975).Google Scholar
  12. 13.
    V. L. N. Murty and M. I. Horowitz, Carbohydr. Res.6, 266 (1968).Google Scholar
  13. 14.
    A. Gottschalk and E. R. B. Graham, Biochim. biophys. Acta38, 513 (1959).Google Scholar
  14. 15.
    M. L. Schneir and M. E. Rafelson, Biochim. biophys. Acta130, 1 (1966).Google Scholar
  15. 16.
    R. V. P. Tao and C. C. Sweeley, Biochim. biophys. Acta218, 372 (1970).Google Scholar
  16. 17.
    S. Moore and W. H. Stein, J. biol. Chem.211, 907 (1954).Google Scholar

Copyright information

© Birkhäuser Verlag 1977

Authors and Affiliations

  • S. W. Hardy
    • 1
  • P. T. Grant
    • 1
  • Thelma C. Fletcher
    • 1
  1. 1.Institute of Marine BiochemistryNatural Environment Research CouncilAberdeen(Scotland)

Personalised recommendations