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Antihypertensive and central nervous system depressant properties of 3-(γ-p-fluorobenzoyl propyl) 2,3,4,4a,5,6-hexahydro-1(H)-pyrazino(1,2-a) quinoline hydrochloride (compound 69-183, centpyraquin)

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Zusammenfassung

Centpyraquin (3-(γ-p-fluorobenzyl propyl) 2,3,4,4a,5,6-hexahydro-1(H)-pyrazino (1,2-a) quinoline hydrochloride) zeigte hypotensive Aktivität bei narkotisierten wie auch bei wachen Katzen. Es senkt auch den Blutdruck bei Ratten mit nephrogenem Hochdurck. Die Hypotension scheint auf einem peripheren Mechanismus zu beruhen.

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References

  1. V. A. Rao, P. C. Jain, N. Anand, R. C. Srimal andP. R. Dua, J. med. Chem.,13, 516 (1970).

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Authors and Affiliations

  1. Chattar Manzil Palace, Central Drug Research Institute, Lucknow-1, India

    G. B. Singh, Swaran Nityanand, R. C. Srimal, V. A. Rao, P. C. Jain & B. N. Dhawan

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  1. G. B. Singh
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  2. Swaran Nityanand
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  3. R. C. Srimal
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  4. V. A. Rao
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  5. P. C. Jain
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  6. B. N. Dhawan
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Additional information

Thanks are due to Drs.M. L. Dhar andN. Anand for their interest in the work.

Communication No. 1600 from the Central Drug Research Institute; Lucknow.

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Singh, G.B., Nityanand, S., Srimal, R.C. et al. Antihypertensive and central nervous system depressant properties of 3-(γ-p-fluorobenzoyl propyl) 2,3,4,4a,5,6-hexahydro-1(H)-pyrazino(1,2-a) quinoline hydrochloride (compound 69-183, centpyraquin). Experientia 29, 1529–1530 (1973). https://doi.org/10.1007/BF01943898

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  • DOI: https://doi.org/10.1007/BF01943898

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