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Development of tolerance toΔ9-THC in the frog

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Résumé

Après injections bi-journalières deΔ 9-THC à des grenouilles, nous avons calculé la durée de la perte du réflexe de redressement. La tolérance auΔ 9-THC fut évidente après la seconde injection et, après la troisième, aucun effect ne fut visible. Ceci suggère que la tolérance se développe par leΔ 9-THC, et non par ses métabolites, puisque les grenouilles n'ont pas de système enzymatique d'hydroxylation.

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Author notes

  1. E. L. Abel

    Present address: New York State Department of Mental Hygiene, Institute on Alcoholism, 1021 Main Street, 14203, Buffalo, New York, USA

Authors and Affiliations

  1. Department of Pharmacology, University of North Carolina, 27514, Chapel Hill, North Carolina, USA

    E. L. Abel

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  1. E. L. Abel
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Abel, E.L. Development of tolerance toΔ9-THC in the frog. Experientia 29, 1527–1528 (1973). https://doi.org/10.1007/BF01943896

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