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Gramicidin S analogs containing N-methylleucine in place of leucine

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Zusammenfassung

Nach Methoden der konventionellen Peptidsynthese wurden zwei Gramicidin S Analoga synthetisiert, in denen Leucin durch N-Methylleucin ersetzt ist. Beim antibakteriellen Test sind diese beiden Analoga praktisch gleich wirksam wie Gramicidin S und auch die Konformation dieser zwei Analoga ist derjenigen von Gramidicin S ähnlich.

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References

  1. D. C. Hodgkin andB. M. Oughton, Biochem. J.65, 752 (1957).

    Article  CAS  Google Scholar 

  2. R. Schwyzer, Chimia12, 53 (1958). —R. Schwyzer andU. Ludesher, Biochemistry7, 2519 (1968).

    CAS  Google Scholar 

  3. A. Stern, W. A. Gibbons andL. C. Craig, Proc. natn. Acad. Sci.61, 734 (1968).

    Article  CAS  Google Scholar 

  4. M. Ohnishi andD. W. Urry, Biochem. biophys. Res. Comm.36, 194 (1969).

    Article  CAS  Google Scholar 

  5. The abbreviations recommended by the IUPAC-IUB Commission on Biochemical Nomenclature [J. biol. Chem.247, 977 (1972)]. have been used throughout. Amino acid symbols exceptd-Phe denote thel-configuration.

  6. 1-Ethyl-3-(3-dimethylaminopropyl)-carbodiimide.

  7. W. König andR. Geiger, Chem. Ber.163, 788 (1970).

    Article  Google Scholar 

  8. S. Matsuura, M. Waki, T. Kato andN. Izumiya, Bull. chem. Soc., Japan46, 977 (1973).

    Article  CAS  Google Scholar 

  9. D. Balasubramanian, J. Am. chem. Soc.89, 5445 (1967).

    Article  CAS  Google Scholar 

  10. G. Vanderkooi, S. J. Leach, G. Némethy, R. Scott andH. A. Scheraga, Biochemistry5, 2991 (1966).

    Article  CAS  Google Scholar 

  11. The authors wish to express their thanks to Dr.I. Chibata of Tanabe Seiyaku Co., Ltd. for his encouragement in the course of this study. Thanks are also due to Associate ProfessorY. Mukohata of Osaka University for help in ORD measurements, and to Dr.K. Enomoto of Tanabe Seiyaku Co., Ltd. for the biological assay.

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Author notes

  1. H. Sugano & M. Miyoshi

    Present address: Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd., Kashima-cho Higashiyodogawa-ku, Osaka, Japan

  2. H. Abe, T. Kato & N. Izumiya

    Present address: Laboratory of Biochemistry, Faculty of Science, Kyushu University, Fukuoka, Japan

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    1. H. Sugano
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    2. H. Abe
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    3. M. Miyoshi
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    4. T. Kato
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    5. N. Izumiya
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    Sugano, H., Abe, H., Miyoshi, M. et al. Gramicidin S analogs containing N-methylleucine in place of leucine. Experientia 29, 1488–1489 (1973). https://doi.org/10.1007/BF01943872

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