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Intraluminal bile salt increases rate of firing in afferent fibers from the small intestine of the rat

Summary

Perfusion of a rat intestinal segment with a solution containing sodium deoxycholate (8 mM) increases the rate of firing in periarterial afferent nerves from the gut. This observation indirectly supports our earlier proposal that bile salt evokes a net fluid secretion in the small intestine via an activation of the enteric nervous system.

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Literatur

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Additional information

This study was supported by grants from the Swedish Medical Research Council (2855), The Medical Council of Swedish Life Insurance Companies and the Faculty of Medicine, University of Göteborg.

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Tantisira, M.H., Jodal, M. & Lundgren, O. Intraluminal bile salt increases rate of firing in afferent fibers from the small intestine of the rat. Experientia 43, 168–169 (1987). https://doi.org/10.1007/BF01942837

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  • DOI: https://doi.org/10.1007/BF01942837

Key words

  • Bile salt
  • intestinal afferent nerves