Experientia

, Volume 42, Issue 3, pp 302–304 | Cite as

Effect of halogenmethylenebisphosphonates on bone cells in culture and on bone resorption in vivo

  • R. Felix
  • H. Fleisch
  • R. Schenk
Short Communications Biochemistry and Biophysics, Metabolism, Neurobiology, Pharmacology

Summary

Dihalogenmethylenebisphosphonates increase alkaline phosphatase activity and fatty acid oxidation in calvaria cells in culture (Cl2MBP>Br2MBP≊F2MBP). The monohalogen C1MBP and the non-halogenated analogues are less active on phosphatase and inactive on or inhibitory towards fatty acid oxidation. The three dihalogenbisphosphonates and C1MBP inhibit bone resorption in vivo, Cl2MBP most strongly.

Key words

Bone cells bisphosphonates lactate production alkaline phosphatase fatty acid oxidation bone resorption 

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Copyright information

© Birkhäuser Verlag Basel 1986

Authors and Affiliations

  • R. Felix
    • 1
  • H. Fleisch
    • 1
  • R. Schenk
    • 1
  1. 1.Department of Pathophysiology and Department of AnatomyUniversity of BernBernSwitzerland

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