Experientia

, Volume 44, Issue 3, pp 251–252 | Cite as

Kinetic arguments for the existence of a single form of intestinal ornithine decarboxylase during the postnatal development of normal and sparse-fur mutant mice and after EGF treatment

Short Communications

Summary

The Km for ornithine is remarkably constant during the course of postnatal development in both normal and spf mutant mice even if a large but transient increase in ornithine decarboxylase (ODC) activity is noted. Four hours after EGF injection (4 μg/g b.wt) to 17-day-old normal and spf mice, a marked stimulation of ODC activity is observed but Km remains unaffected. These data argue against the existence of multiple forms of ODC in the intestinal mucosa of mice.

Key words

Ornithine decarboxylase small intestine postnatal development kinetic properties EGF treatment sparse-fur mutant mice 

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Copyright information

© Birkhäuser Verlag 1988

Authors and Affiliations

  • C. Malo
    • 1
  1. 1.Department of Physiology, Faculty of MedicineUniversity of MontrealMontréalCanada

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