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Suppression by LH-releasing hormone (LHRH) of the augmenting effect of estradiol on the secretion of LH and FSH by the rat pituitary gland

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Summary

Estradiol sensitizes the pituitary gland for the gonadotropin-releasing activity of LHRH. LHRH desensitizes the pituitary gland and does so in a dose-dependent manner. Moreover, LHRH dose-dependently suppresses the sensitizing effect of EB. In rats with an LHRH concentration in the plasma of about 90 pg/ml, the sensitizing effect of estradiol is absent.

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Authors and Affiliations

  1. Division of Reproductive Biology, Department of Obstetrics and Gynaecology, University of Groningen, 59 Oostersingel, NL-9713 EZ, Groningen, The Netherlands

    G. A. Schuiling, N. Pols-Valkhof & T. R. Koiter

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  1. G. A. Schuiling
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  2. N. Pols-Valkhof
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  3. T. R. Koiter
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Schuiling, G.A., Pols-Valkhof, N. & Koiter, T.R. Suppression by LH-releasing hormone (LHRH) of the augmenting effect of estradiol on the secretion of LH and FSH by the rat pituitary gland. Experientia 44, 235–238 (1988). https://doi.org/10.1007/BF01941719

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  • DOI: https://doi.org/10.1007/BF01941719

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