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Experientia

, Volume 44, Issue 3, pp 230–232 | Cite as

Preferential cytotoxicity on tumor cells by caffeic acid phenethyl ester isolated from propolis

  • D. Grunberger
  • R. Banerjee
  • K. Eisinger
  • E. M. Oltz
  • L. Efros
  • M. Caldwell
  • V. Estevez
  • K. Nakanishi
Short Communications

Summary

The honeybee hive product, propolis, is a folk medicine employed for treating various ailments. Many important pharmaceutical properties have been ascribed to propolis, including anti-inflammatory, antiviral, immunostimulatory and carcinostatic activities. Propolis extracts have provided an active component identified as caffeic acid phenethyl ester (CAPE), which was readily prepared in one step. Differential cytotoxicity has been observed in normal rat/human versus transformed rat/human melanoma and breast carcinoma cell lines in the presence of CAPE.

Key words

Honebee hive propolis caffeic acid ester cytoxicity 

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Copyright information

© Birkhäuser Verlag 1988

Authors and Affiliations

  • D. Grunberger
    • 2
    • 1
  • R. Banerjee
    • 2
    • 1
  • K. Eisinger
    • 3
    • 1
  • E. M. Oltz
    • 4
    • 1
  • L. Efros
    • 4
    • 1
  • M. Caldwell
    • 4
    • 1
  • V. Estevez
    • 4
    • 1
  • K. Nakanishi
    • 4
    • 1
  1. 1.Comprehensive Cancer Center, College of Physicians and SurgeonsColumbia UniversityNew YorkUSA
  2. 2.Institute of Cancer Research, College of Physicians and SurgeonsColumbia UniversityNew YorkUSA
  3. 3.Department of Biological SciencesColumbia UniversityNew YorkUSA
  4. 4.Department of ChemistryColumbia UniversityNew YorkUSA

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