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Enhanced reactivity towards flunarizine in cerebrovascular bed of spontaneously hypertensive rats

Experientia volume 44, pages 221–222 (1988)Cite this article

Summary

Cerebral blood flow (CBF) was measured and cerebrovascular resistance (CVR) was calculated in anesthetized spontaneously hypertensive rats (SHR) and normotensive rats (NR) following the administration of incremental dosages of i.v. flunarizine or papaverine. CBF and CVR changes following papaverine were the same in both groups of rats irrespective of the dose of the drug. The effect of flunarizine was much more pronounced in SHR than in NR. The results point out the greater dependency of basal cerebrovascular tone in SHR upon Ca2+ influx into vascular smooth muscle cells.

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References

  1. Nordborg, C., and Johansson, B. B., Stroke11 (1980) 266.

    PubMed  Google Scholar 

  2. Folkow, B., Physiol. Rev.62 (1982) 347.

    PubMed  Google Scholar 

  3. Johansson, B. B., and Nilsson, B., Stroke10 (1979) 572.

    PubMed  Google Scholar 

  4. DeQuatro, V., Sullivan, P., Minagawa, R., Kopin, L., Bornheimer, J. Foti, A., and Barndt, R., Fedn Proc.43 (1984) 47.

    Google Scholar 

  5. Noon, J. P., Rice, P. J., and Baldessarini, P. J., Proc. natl Acad. Sci. USA75 (1978) 1605.

    PubMed  Google Scholar 

  6. Hulthén, U. L., Bolli, P., Amann, F. W., Kiowski, W., and Bühler, F. R., Hypertension,4, Suppl. II (1982) II-26.

    Google Scholar 

  7. Van Nueten, J. M., Van Beek, J., and Janssen, P. A. J., Archs int. Pharmacodyn. Ther.232 (1978) 42.

    Google Scholar 

  8. Van Nueten, J. M., Van Beek, J., and Janssen, P. A. J., Arzneim.-Forsch.11 (1978) 2082.

    Google Scholar 

  9. Van Nueten, J. M., in: Calcium Modulators, p. 199. Eds. T. Godfraind, A. Albertini and R. Paoletti. Elsevier Biomedical Press, Amsterdam 1982.

    Google Scholar 

  10. Dempsey, F., and Godfraind, T., Archs int. Pharmacodyn.199 (1972). 195.

    Google Scholar 

  11. Broekaert, A., and Godfraind, T., Eur. J. Pharmac.53 (1979) 281.

    Google Scholar 

  12. Hertz, M. M., Hemmingsen, R., and Bolwig, T., Acta physiol. scand.105 (1977) 501.

    Google Scholar 

  13. Spedding, M., Trends pharmac. Sci.6 (1985) 109.

    Google Scholar 

  14. Van Nueten, J. M., and Wellens, D., Angiology30 (1979) 440.

    PubMed  Google Scholar 

  15. Spedding, M., Br. J. Pharmac.79 (1983) 225.

    Google Scholar 

  16. Thorens, S., and Haeusler, G., Eur. J. Pharmac.54 (1979) 79.

    Google Scholar 

  17. Reuter, H., Nature, Lond.301, (1983) 569.

    Google Scholar 

  18. Postnov, Y. V., and Orlov, S. N., J. Hypertension2 (1984) 1.

    Google Scholar 

  19. Robinson, B. F., J. Hypertension2 (1984) 453.

    Google Scholar 

Download references

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Affiliations

  1. Department of Clinical and Applied Physiology, Institute of Physiological Sciences, School of Medicine, Krakowskie Przedmiescie 26/28, 00-927, Warsaw, (Poland)

    E. Koźniewska

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  1. E. Koźniewska
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Koźniewska, E. Enhanced reactivity towards flunarizine in cerebrovascular bed of spontaneously hypertensive rats. Experientia 44, 221–222 (1988). https://doi.org/10.1007/BF01941712

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  • DOI: https://doi.org/10.1007/BF01941712

Key words

  • Cerebral blood flow
  • cerebrovascular resistance
  • SHR
  • NR
  • flunarizine
  • papaverine