Skip to main content

Spatial variation in response to odorants on the rat olfactory epithelium

Summary

We have measured the electro-olfactogram produced by four odorants, nicotine, i-pentyl acetate, i-pentanoic acid and cineole from twelve positions on an in vitro preparation of rat olfactory tissue. Each odorant shows a different pattern of response over the twelve positions which can be explained by differences in olfactory receptor populations between regions of the rat olfactory epithelium.

The result for nicotine is further evidence that there are olfactory receptors which are stimulated by nicotine when it is presented as a vapour.

This is a preview of subscription content, access via your institution.

References

  1. Getchell, T. V., Physiol. Rev.66 (1986) 772.

    PubMed  Google Scholar 

  2. Lancet, D., A. Rev. Neurosci.9 (1986) 329.

    Google Scholar 

  3. Mozell, M. M., and Jagodowicz, M., Science (Washington)181 (1973) 1247.

    Google Scholar 

  4. Getchell, T. V., Margolis, F. L., and Getchell, M. L., Prog. Neurobiol.23 (1984) 317.

    PubMed  Google Scholar 

  5. Shirley, S. G., Polak, E. H., Edwards, D. A., Wood, M. A., and Dodd, G. H., Biochem. J.245 (1987) 185.

    PubMed  Google Scholar 

  6. Shirley, S. G., Polak, E. H., Mather, R. A., and Dodd, G. H., Biochem. J.245 (1987) 175.

    PubMed  Google Scholar 

  7. Revial, M. F., Sicard, G., Duchamp, A., and Holley, A., Chem. Senses7 (1982) 175.

    Google Scholar 

  8. Shirley, S. G., Robinson, C. J., Dickinson, K., Aujla, R., and Dodd, G. H., Biochem. J.240 (1986) 605.

    PubMed  Google Scholar 

  9. Sklar, P. B., Anholt, R. R. H., and Snyder, S. H., J. biol. Chem.261 (1986) 15538.

    PubMed  Google Scholar 

  10. Mustaparta, H., Acta. physiol. scand.82 (1971) 154.

    PubMed  Google Scholar 

  11. Daval, G., Leveteau, J., and MacLeod, P., J. Physiol. Paris76 (1980) 559.

    PubMed  Google Scholar 

  12. Mackay-Sim, A., and Kubie, J. L., Chem. Senses6 (1981) 249.

    Google Scholar 

  13. Menco, B. Ph. M., in: Nasal Tumors in Animals and Man, vol. 1, p. 45. Eds G. Reznik and S. F. Stinson. CRC Press, Florida 1983.

    Google Scholar 

  14. Pederson, P. E., Jastreboff, P. J., Stewart, W. B., and Shepherd, G. M., J. comp. Neurobiol.250 (1986) 93.

    Google Scholar 

  15. Astic, L., and Saucier, D., Brain Res. Bull.16 (1986) 445.

    PubMed  Google Scholar 

  16. Saucier, D., and Astic, L., Brain Res. Bull.16 (1986) 455.

    PubMed  Google Scholar 

  17. Thommesen, G., and Doving, K. B., Acta. physiol. scand.99 (1977) 270.

    PubMed  Google Scholar 

  18. Edwards, D. A., Mather, R. A., Shirley, S. G., and Dodd, G. H., Experientia43 (1987) 868.

    PubMed  Google Scholar 

  19. Menco, B. Ph. M., Cell Tissue Res.207 (1980) 183.

    PubMed  Google Scholar 

  20. Shirley, S. G., Chem. Senses (1987) in press.

  21. Pevsner, J., Sklar, P. B., and Snyder, S. H., Proc. natl Acad. Sci. USA83 (1986) 4942.

    PubMed  Google Scholar 

Download references

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Edwards, D.A., Mather, R.A. & Dodd, G.H. Spatial variation in response to odorants on the rat olfactory epithelium. Experientia 44, 208–211 (1988). https://doi.org/10.1007/BF01941707

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01941707

Key words

  • Electro-olfactogram
  • olfaction
  • spatial patterning
  • nicotine