, Volume 42, Issue 10, pp 1174–1176 | Cite as

Teratogenic effects of cadmium onBufo arenarum during gastrulation

  • C. S. Perez-Coll
  • J. Herkovits
  • A. Salibián


DevelopingBufo arenarum embryos were treated during gastrulation with cadmium chloride in concentrations ranging from 6×10−7 to 1.5×10−5 M Cd++ at 20 and 30°C. Initial failures at gastrulation result mainly in axial incurvations, microcephaly, hydropsy and abnormal tail formation. The higher temperature has a dual effect: at high concentrations of Cd early malformations are significantly increased, whereas at low concentrations the higher temperature prevents alterations.

Key words

Teratogenesis cadmium temperature dependence amphibian gastrulae 


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  1. 4.
    Williams, C.R., and Harrison, R.M., Experientia40 (1984) 29.Google Scholar
  2. 5.
    Ravera, O., Experientia40 (1984) 2.Google Scholar
  3. 6.
    Rosenthal, H., and Alderdice, D.F., J. Fish. Res. Board Can.33 (1976) 2047.Google Scholar
  4. 7.
    Pérez-Coll, C.S., Herkovits, J., and Salibián, A., Arch. Biol. Med. exp.18 (1985) 33.Google Scholar
  5. 8.
    Pérez-Coll, C.S., Herkovits, J., and Salibián, A., Medicina43 (1983) 816.Google Scholar
  6. 9.
    Herkovits, J., Doctoral thesis, Faculty of Medicine, University of Buenos Aires, 1978.Google Scholar
  7. 10.
    Jackim, E., Morrison, G., and Steele, R., Mar. Biol.40 (1977) 303.Google Scholar
  8. 11.
    Del Conte, E., and Sirlin, J.L., Acta zool. Lilloana12 (1951) 495.Google Scholar
  9. 12.
    Herkovits, J., Experientia33 (1977) 510.Google Scholar
  10. 13.
    Jones, M.B., Mar. Biol.30 (1975) 13.Google Scholar
  11. 14.
    Voyer, R.A., Wentworth, C.E., Barry, E.P., and Hennekey, R.J., Mar. Biol.44 (1977) 117.Google Scholar
  12. 15.
    Thurberg, F.P., Dawson, M.A., and Collier, R.S., Mar. Biol.23 (1973) 171.Google Scholar
  13. 16.
    Muramoto, S., Envir. Pollut.24 (1981) 125.Google Scholar
  14. 17.
    Bundit, V., Vare, A.M., and Monie, I.W., Teratology13 (1976) 18.Google Scholar
  15. 18.
    Jacobson, K.B., and Turner, J.E., Toxicology16 (1980) 1.Google Scholar
  16. 19.
    Vallee, B.C., and Ulmer, D.D., A. Rev. Biochem.41 (1972) 91.Google Scholar

Copyright information

© Birkhäuser Verlag 1986

Authors and Affiliations

  • C. S. Perez-Coll
    • 1
  • J. Herkovits
    • 1
  • A. Salibián
    • 1
  1. 1.Instituto de Biología de la Reproducción y Desarrollo EmbrionarioUniversidad Nacional de Lomas de Zamora, C. C. 95Lomas de Zamora(B. A. Argentina)

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