Skip to main content
SpringerLink
Log in

Corticosteroid effects on cholinergic enzymes in ethanol-treated fetal brain cell cultures

  • Short Communications
  • Published:
Experientia Aims and scope Submit manuscript

Summary

In the presence of ethanol, corticosterone and dexamethasone inhibit choline acetyltransferase and acetylcholinesterase activities in cultured fetal brain cells of the rat. These results suggest that corticosteroids may have an important influence on the activity of cholinergic enzymes in the fetal brain and may antagonize the effects of ethanol in this setting.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Okonmah, A. D., Brown, J. W., Fishman, L. M. Carballeira, A., and Soliman, K. F. A., Proceedings of the 68th Annual Meeting of the Endocrine Society, 1986, abstr. p. 970.

  2. Abel, E. L., Psychol. Bull.87 (1978) 29.

    Article  Google Scholar 

  3. Jones, K. L., Smith, D. W., Ulleland, C. N., and Streissguth, A. P., Lancet2 (1973) 1267.

    Article  Google Scholar 

  4. Randall, C. L., in: Alcohol and Health Monograph, No. 2, Biomedical Processes and Consequences of Alcohol Use. U.S. Government Printing Office, Washington, DC 1982.

    Google Scholar 

  5. Brown, J. W., Carballeira, A., Soliman, K. F. A., and Fishman, L. M., I.C.S.U. Short Rep.4 (1986) 270.

    Google Scholar 

  6. Chao, L. and Wolfgram, F., Analyt. Biochem.46 (1972) 114.

    Article  CAS  PubMed  Google Scholar 

  7. Ellman, G. L., Courtney, K. D., Andres, V. Jr, and Featherstone, R. M., Biochem. Pharmac.7 (1961) 88.

    Article  CAS  Google Scholar 

  8. Knigge, K. M., Hoffman, G., Scott, D. E., and Sladek, J. R. Jr, Brain Res.120 (1977) 393.

    Article  CAS  PubMed  Google Scholar 

  9. Sumners, C., and Raizada, M. K., Am. J. Physiol.246 (1984) C-502.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Medical Research Service, Veterans Administration Medical Center and Department of Medicine, University of Miami School of Medicine, 33125, Miami, Florida, USA

    J. W. Brown, A. Carballeira & L. M. Fishman

  2. College of Pharmacy, Florida A & M University Clinical Research Unit, P.O. Box 421091, 33142, Miami, Florida, USA

    A. D. Okonmah

  3. College of Pharmacy, Florida A & M University, 32307, Tallahassee, Florida, USA

    K. F. A. Soliman

Authors
  1. J. W. Brown
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. D. Okonmah
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. K. F. A. Soliman
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. Carballeira
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. L. M. Fishman
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Brown, J.W., Okonmah, A.D., Soliman, K.F.A. et al. Corticosteroid effects on cholinergic enzymes in ethanol-treated fetal brain cell cultures. Experientia 44, 898–900 (1988). https://doi.org/10.1007/BF01941195

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01941195

Key words

Search

Navigation