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Interaction of atropine or methylatropinium with four effects of two cholinergic drugs

Experientia volume 32, pages 371–372 (1976)Cite this article

Summary

In mice, pilocarpine — or oxotremorine — induced decrease in locomotor activity and increase of the reaction time to pain were antagonized by atropine and not by methylatropinium. Identical doses of atropine and methylatropinium suppressed the antagonism of the cholinergics towards reserpine-induced palpebral ptosis. Cholinergics-induced hypothermia was not clearly antagonized by atropine or methylatropinium.

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Affiliations

  1. Départment de Pharmacologie, Faculté de Médecine Pitié-Salpétrière, 91, Boulevard de l'Hôpital, F-75634, Paris-Cedex 13, (France)

    P. Simon, R. Chermat & J. R. Boissier

Authors
  1. P. Simon
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  2. R. Chermat
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  3. J. R. Boissier
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Simon, P., Chermat, R. & Boissier, J.R. Interaction of atropine or methylatropinium with four effects of two cholinergic drugs. Experientia 32, 371–372 (1976). https://doi.org/10.1007/BF01940845

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  • DOI: https://doi.org/10.1007/BF01940845

Keywords

  • Reaction Time
  • Locomotor Activity
  • Atropine
  • Pilocarpine
  • Identical Dose