, Volume 32, Issue 3, pp 362–365 | Cite as

Diphasic action of the aliphatic amide, HOE 17879, on hepatic microsomal drug metabolizing enzymes in the mouse

  • F. E. Beyhl
  • E. Lindner


α-Hydroxy-α-ethylbutyryl-diethylamide (HOE 17879) influences the hepatic microsomal drug hydroxylating enzyme system of mice in a two-phasic way: First it reduces the overall reaction of drug hydroxylation but not the single enzymes whilst in the second period it increases enzyme activities.


Enzyme Enzyme Activity Amide Enzyme System Single Enzyme 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Birkhäuser Verlag 1976

Authors and Affiliations

  • F. E. Beyhl
    • 1
  • E. Lindner
    • 1
  1. 1.Pharma ForschungHoechst AG.Frankfurt am Main 80(German Federal Republic, BRD)

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