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Experientia

, Volume 32, Issue 3, pp 280–282 | Cite as

A possible chemical basis for the higher mutagenicity of marijuana smoke as compared to tobacco smoke

  • M. Novotny
  • M. L. Lee
  • K. D. Bartle
Article

Summary

The results of comparative analyses of polynuclear aromatic hydrocarbons in marijuana and tobacco smoke indicate a considerably higher content of potential carcinogens in the former. A model experiment involving Δ9-tetrahydrocannabinol suggests that the pyrolysis products of cannabinoids are major contributors to the polynuclear aromatic hydrocarbons.

Keywords

Hydrocarbon Pyrolysis Comparative Analysis Smoke Model Experiment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 3.
    T. H. Maugh II, Science185, 683 (1974).Google Scholar
  2. 4.
    C. Leuchtenberger andR. Leuchtenberger, Nature, Lond.234, 227 (1971).Google Scholar
  3. 5.
    C. Leuchtenberger, R. Leuchtenberger andA. Schneider, Nature, Lond.241, 137 (1973).Google Scholar
  4. 6.
    C. Leuchtenberger, R. Leuchtenberger, U. Ritter andN. Inui, Nature, Lond.242, 403 (1973).Google Scholar
  5. 7.
    F. Seehofer andJ. E. Miller, Beitr. Tabakforsch.3, 75 (1965).Google Scholar
  6. 8.
    M. Novotny, M. L. Lee andK. D. Bartle, J. Chromatogr. Sci.12, 606 (1974).PubMedGoogle Scholar
  7. 9.
    M. L. Lee, M. Novotny andK. D. Bartle, Analyt. Chem., in press (1975).Google Scholar
  8. 10.
    D. Hoffmann andE. L. Wynder, Z. Krebsforsch.68, 137 (1966).CrossRefPubMedGoogle Scholar
  9. 11.
    A. Sellakumar andP. Shubik, J. natn. Cancer Inst.53, 1713 (1974).Google Scholar
  10. 12.
    G. M. Badger, J. D. Donnelly andT. M. Spotswood, Austr. J. Chem.18, 1249 (1965).Google Scholar
  11. 13.
    D. Hoffmann, G. Rathkamp, K. D. Brunnemann andE. L. Wynder, Sci. Tot. Envir.2, 157 (1973).CrossRefGoogle Scholar
  12. 14.
    C. J. Keller, L. P. Bush andC. Grunwald, J. agric Food Chem.17, 331 (1969).CrossRefGoogle Scholar
  13. 15.
    J. W. Fairbairn andJ. A. Liebmann, J. Pharm. Pharmac.26, 413 (1974).Google Scholar
  14. 16.
    M. Novotny andR. Farlow, J. Chromatogr.103, 1 (1975).CrossRefGoogle Scholar

Copyright information

© Birkhäuser Verlag 1976

Authors and Affiliations

  • M. Novotny
    • 1
    • 2
  • M. L. Lee
    • 1
    • 2
  • K. D. Bartle
    • 1
    • 2
  1. 1.Department of ChemistryIndiana UniversityBloomingtonUSA
  2. 2.Department of Physical ChemistryUniversity of LeedsLeeds(England)

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