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Effects of serotonin and ketanserin on the functional morphology of chick down feather bulbi in vitro

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Chick feather bulbi cultured in vitro showed an increased DNA synthesis and a delayed keratinization after treatment with ketanserin, a serotonin2 antagonist with wound-healing properties. In contrast, serotonin stimulates keratinization of the keratinocytes in the bulbus.

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Beele, H., Thierens, H., Verhasselt, B. et al. Effects of serotonin and ketanserin on the functional morphology of chick down feather bulbi in vitro. Experientia 46, 1057–1060 (1990).

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Key words

  • Organotypic cultures
  • feather bulbus
  • keratinocytes
  • serotonin
  • ketanserin