Skip to main content
Log in

A new cellular function for peroxisomes related to oxygen free radicals?

  • Review
  • Published:
Experientia Aims and scope Submit manuscript

Summary

Although in cell biology peroxisomes are still ‘young’ organelles, it is becoming increasingly clear that they are involved in important cellular functions. Recent results have indicated the presence of the metalloenzyme superoxide dismutase in peroxisomes and the production of superoxide free radicals (O 2 ) in these oxidative organelles. These findings, together with other experimental evidence, point towards the existence of new roles for peroxisomes in cellular active oxygen metabolism, something that has a potential impact in multiple areas of cell biology, particularly in biochemistry and biomedicine.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Literature

  1. Angermüller, S., Bruder, G., Völkl, A., Wesch, H., and Fahimi, H. D., Localization of xanthine oxidase in crystalline cores of peroxisomes. A cytochemical and biochemical study. Eur. J. Cell Biol.45 (1987) 137–144.

    PubMed  Google Scholar 

  2. Byczkowski, J. Z., and Gessner, T., Biological role of superoxide ionradical. Int. J. Biochem.20 (1988) 569–580.

    Article  CAS  PubMed  Google Scholar 

  3. De Duve, C., and Baudhuin, P., Peroxisomes (microbodies and related particles). Physiol. Rev.46 (1966) 323–357.

    Article  PubMed  Google Scholar 

  4. De Duve, C., Beaufay, H., Jacques, P., Rahman-Li, Y., Sellinger, O. Z., Wattiaux, R., and De Conninck, S., Intracellular localization of catalase and of some oxidases in rat liver. Biochim. biophys. Acta40 (1960) 186–187.

    Article  PubMed  Google Scholar 

  5. Del Río, L. A., Fernández, V. M., Rupérez, F. L., Sandalio, L. M., and Palma, J. M., NADH induces the generation of superoxide radicals in leaf peroxisomes. Plant Physiol.89 (1989) 728–731.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Del Río, L. A., Lyon, D. S., Olah, I., Glick, B., and Salin, M. L., Immunocytochemical evidence for a peroxisomal localization of manganese superoxide dismutase in leaf protoplasts from a higher plant. Planta158 (1983) 216–224.

    Article  PubMed  Google Scholar 

  7. Droillard, M. J., Rôle joué par les radicaux libres et les superoxyde dismutases au cours de la sénescence du petale d'oeillet coupé (Dianthus caryophyllus L., cv. Ember) Ph.D. Thesis, Paris VI University, Paris 1990.

    Google Scholar 

  8. Elstner, E. F., Metabolism of activated oxygen species, in: The Biochemistry of Plants, vol. 11, pp. 253–315. Ed. D. D. Davies. Academic Press, London 1987.

    Google Scholar 

  9. Fahimi, H. D., and Sies, H. (Eds), Peroxisomes in Biology and Medicine. Springer-Verlag, Berlin-Heidelberg 1987.

    Google Scholar 

  10. Fang, T. K., Donaldson, R. P., and Vigil, E. L., Electron transport in purified glyoxysomalmembranes from castor-bean endosperm. Planta172 (1987) 1–13.

    Article  CAS  PubMed  Google Scholar 

  11. Fifth Conference on Superoxide and Superoxide Dismutase, Jerusalem, 17–22 September 1989.

  12. Flaherty, J. T., and Weisfeldt, M. L., Reperfusion injury. Free Radical Biol. Med.5 (1988) 409–419.

    Article  CAS  Google Scholar 

  13. Fridovich, I., Superoxide dismutases, in: Advances in Enzymology and Related Areas of Molecular Biology, vol. 58, pp. 61–97. Ed. A. Meister. John Wiley Sons, New York 1986.

    Google Scholar 

  14. Fridovich, I., Biological effects of the superoxide radical. Archs Biochem. Biophys.247 (1986) 1–11.

    Article  CAS  Google Scholar 

  15. Gerhardt, B., Basic metabolic function of the higher plant peroxisome. Physiol. Vég.24 (1986) 397–410.

    CAS  Google Scholar 

  16. Goel, S. K., Lalwani, N. D., and Reddy, J. K., Peroxisome proliferation and lipid peroxidation in rat liver. Cancer Res.46 (1986) 1324–1330.

    CAS  PubMed  Google Scholar 

  17. Halliwell, B., Oxidants and human disease: some new concepts. FASEB J.1 (1987) 358–364.

    Article  CAS  PubMed  Google Scholar 

  18. Halliwell, B., and Gutteridge, J. M. C., Free Radicals in Biology and Medicine. Oxford University Press, London 1990.

    Google Scholar 

  19. Huang, A. H. C., Trelease, R. N., and Moore, T. S., Plant Peroxisomes. Academic Press, New York 1983.

    Google Scholar 

  20. Kindl, H., and Lazarow, P. B. (Eds), Peroxisomes and Glyoxysomes. The New York Academy of Sciences, New York 1982.

    Google Scholar 

  21. McCord, J. M., The role of superoxide in postischemic tissue injury, in: Superoxide Dismutase, vol. 3, pp. 143–150. Ed. L. W. Oberley. CRC Press, Inc., Boca Raton, Florida 1985.

    Google Scholar 

  22. Oberley, L. W. (Ed.), Superoxide Dismutase, vol. 3. CRC Press, Inc., Boca Raton, Florida 1985.

    Google Scholar 

  23. Palma, J. M., Garrido, M., Rodriguez-Garcia, M. I., and del Río, L. A., Effect of a hypolipidemic drug (clofibrate) on the metabolism of activated oxygen in leaf peroxisomes. Abstracts of the Fifth Conference on Superoxide and Superoxide Dismutase, p. 171. Jerusalem, 17–22 September 1989.

  24. Palma, J. M., Gómez, M., Yáñez, J., and del Río, L. A., Increased levels of peroxisomal active oxygen-related enzymes in copper-tolerant pea plants. Plant Physiol.85 (1987) 570–574.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Patton, S. E., Rosen, G. M., and Rauckman, E. J., Superoxide production by purified hamster nuclei. Molec. Pharmac.18 (1980) 588–593.

    CAS  Google Scholar 

  26. Pryor, W. A., Oxy-radicals and related species: their formation, life-times and reactions. A. Rev. Physiol.48 (1986) 657–667.

    Article  CAS  Google Scholar 

  27. Reddy, J. K., Azarnoff, D. L., and Hignite, C. E., Hypolipidaemic hepatic peroxisome proliferators form a novel class of chemical carcinogens. Nature283 (1980) 397–398.

    Article  CAS  PubMed  Google Scholar 

  28. Reddy, J. K., and Rao, M. S., Peroxisome proliferators and cancer: mechanisms and implications. Trends Pharmac. Sci.7 (1986) 438–443.

    Article  CAS  Google Scholar 

  29. Reddy, J. K., Rao, M. S., Lalwani, N. D., Reddy, M. K., Nemali, M. R., and Alvares, K., Induction of hepatic peroxisome proliferation by xenobiotics, in: Peroxisomes in Biology and Medicine, pp. 254–262. Eds H. D. Fahimi and H. Sies. Springer-Verlag, Berlin-Heidelberg 1987.

    Google Scholar 

  30. Rotilio, G. (Ed.), Superoxide and Superoxide Dismutase in Chemistry, Biology and Medicine. Elsevier Science Publishers, Amsterdam 1986.

    Google Scholar 

  31. Sandalio, L. M., and del Río, L. A., Localization of superoxide dismutase in glyoxysomes fromCitrullus vulgaris. Functional implications in cellular metabolism. J. Plant Physiol.127 (1987) 395–409.

    Article  CAS  Google Scholar 

  32. Sandalio, L. M., and del Río, L. A., Intraorganellar distribution of superoxide dismutase in plant peroxisomes (glyoxysomes and leaf peroxisomes). Plant Physiol.88 (1988) 1215–1218.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Sandalio, L. M., Fernández, V. M., Rupérez, F. L., and del Río, L. A., Superoxide free radicals are produced in glyoxysomes. Plant Physiol.87 (1988) 1–4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. Sandalio, L. M., Palma, J. M., and del Río, L. A., Localization of manganese superoxide dismutase in peroxisomes isolated fromPisum sativum. Plant Sci.51 (1987) 1–8.

    Article  CAS  Google Scholar 

  35. Schubert, K. R., Products of biological nitrogen fixation in higher plants: Synthesis, transport, and metabolism. A. Rev. Plant Physiol.37 (1986) 539–574.

    Article  CAS  Google Scholar 

  36. Schutgens, R. B. H., Heymans, H. S. A., Wanders, R. J. A., Bosch, H. v. d., and Tager, J. M., Peroxisomal disorders: a newly recognized group of genetic diseases. Eur. J. Pediatr.144 (1986) 430–440.

    Article  CAS  PubMed  Google Scholar 

  37. Tolbert, N. E., and Essner, E., Microbodies: Peroxisomes and Glyoxysomes. J. Cell Biol.91 (1981) 271s-283s.

    Article  CAS  PubMed  Google Scholar 

  38. Tolbert, N. E., Metabolic pathways in peroxisomes and glyoxysomes. A. Rev. Biochem.50 (1981) 133–157.

    Article  CAS  Google Scholar 

  39. Tolbert, N. E., Photorespiration, in: The Biochemistry of Plants, vol. 2, pp. 487–523. Ed. D. D. Davies. Academic Press, London 1980.

    Google Scholar 

  40. Tolbert, N. E., Gee, R., Husic, D. W., and Dietrich, S., Peroxisomal glycolate metabolism and the C2 oxidative photosynthetic carbon cycle, in: Peroxisomes in Biology and Medicine, pp. 213–222. Eds H. D. Fahimi and H. Sies. Springer-Verlag, Berlin-Heidelberg 1987.

    Chapter  Google Scholar 

  41. Turrens, J. F., Beconi, M., Barilla, J., and McCord, J. M., Mitochondrial generation of oxygen radicals during reoxygenation of ischemic tissues. Abstracts of the Fifth Conference on Superoxide and Superoxide Dismutase, p. 26. Jerusalem, 17–22 September 1989.

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

del Río, L.A., Sandalio, L.M. & Palma, J.M. A new cellular function for peroxisomes related to oxygen free radicals?. Experientia 46, 989–992 (1990). https://doi.org/10.1007/BF01940651

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01940651

Key words

Navigation